Diphtheria fusion protein therapy of chemoresistant malignancies.
Frankel AE, Rossi P, Kuzel TM, Foss F. Diphtheria fusion protein therapy of chemoresistant malignancies. Current Cancer Drug Targets 2002, 2: 19-36. PMID: 12188918, DOI: 10.2174/1568009023333944.Peer-Reviewed Original ResearchConceptsTargeted toxinsFusion protein therapyDiphtheria toxinChemotherapy-refractory cancersSelective ligandsTumor-selective ligandsChemoresistant diseaseCombination chemotherapyNeoplastic stem cellsRefractory cancerChemoresistant malignancyGroup IPseudomonas exotoxinWidespread cancerTherapyCell functionCancer therapyAntiviral proteinProtein therapyCancerToxin