2018
Prolonged Overall Survival (OS) in a Subset of Responders to the Combination of Brentuximab Vedotin (Bv) and Bendamustine (B) in Heavily Treated Patients with Relapsed or Refractory Hodgkin Lymphoma (HL): Results of an International Multi- Center Phase I/II Experience
Sawas A, Kuruvilla J, Lue J, Deng C, Amengual J, Montanari F, Savage K, Elgedawe H, Villa D, Crump M, Connors J, O'Connor O. Prolonged Overall Survival (OS) in a Subset of Responders to the Combination of Brentuximab Vedotin (Bv) and Bendamustine (B) in Heavily Treated Patients with Relapsed or Refractory Hodgkin Lymphoma (HL): Results of an International Multi- Center Phase I/II Experience. Blood 2018, 132: 2907. DOI: 10.1182/blood-2018-99-117251.Peer-Reviewed Original ResearchAutologous stem cell transplantProgression-free survivalRefractory Hodgkin lymphomaComplete response rateDose limiting toxicitiesHigh-dose chemotherapyOverall response rateHodgkin's lymphomaBrentuximab vedotinOverall survivalDay 1Partial responseMedian numberDose levelsPrior autologous stem cell transplantResponse rateAutologous stem cell transplantationSeattle GeneticsPhase II dosePhysician's choice chemotherapyPrior radiation therapyPrior systemic therapyLong-term respondersSubset of patientsEvidence of relapse
2014
Relapsed Hodgkin Lymphoma: Management Strategies
Montanari F, Diefenbach C. Relapsed Hodgkin Lymphoma: Management Strategies. Current Hematologic Malignancy Reports 2014, 9: 284-293. PMID: 24942298, PMCID: PMC4909353, DOI: 10.1007/s11899-014-0220-7.Peer-Reviewed Original ResearchConceptsStem cell transplantAutologous stem cell transplantHigh-dose chemotherapyCell transplantHodgkin's lymphomaAllogeneic hematopoietic stem cell transplantHematopoietic stem cell transplantChemotherapy-refractory diseaseRelapsed Hodgkin lymphomaTransient disease controlElderly patient populationFirst-line therapyManagement of patientsBrentuximab vedotinDose chemotherapyRefractory diseaseComplete responseConventional therapyPatient populationNovel therapiesNew agentsPatientsDisease controlTransplantTherapy