2016
The Epstein-Barr Virus Immunoevasins BCRF1 and BPLF1 Are Expressed by a Mechanism Independent of the Canonical Late Pre-initiation Complex
McKenzie J, Lopez-Giraldez F, Delecluse HJ, Walsh A, El-Guindy A. The Epstein-Barr Virus Immunoevasins BCRF1 and BPLF1 Are Expressed by a Mechanism Independent of the Canonical Late Pre-initiation Complex. PLOS Pathogens 2016, 12: e1006008. PMID: 27855219, PMCID: PMC5113994, DOI: 10.1371/journal.ppat.1006008.Peer-Reviewed Original ResearchMeSH KeywordsBlotting, WesternChromatin ImmunoprecipitationEpstein-Barr Virus InfectionsGene Expression Regulation, ViralGene Knockdown TechniquesHEK293 CellsHerpesvirus 4, HumanHigh-Throughput Nucleotide SequencingHumansImmune EvasionReal-Time Polymerase Chain ReactionViral ProteinsViral Regulatory and Accessory ProteinsViral Structural ProteinsConceptsPre-initiation complexViral pre-initiation complexEpstein-Barr virusLate genesViral gene expressionGene regulatorsViral structural proteinsGene expressionStructural proteinsImmunomodulatory proteinsHost immune surveillanceAntiviral immune responseChIP-seq analysisProtein kinase BGLF4Presence of siRNAsEB virusPrimary infectionImmune surveillanceImmune responseAntiviral drugsImmune evasionGene productsViral pathogenesisBCRF1Gamma herpesvirus
2014
A Locus Encompassing the Epstein-Barr Virus bglf4 Kinase Regulates Expression of Genes Encoding Viral Structural Proteins
El-Guindy A, Lopez-Giraldez F, Delecluse HJ, McKenzie J, Miller G. A Locus Encompassing the Epstein-Barr Virus bglf4 Kinase Regulates Expression of Genes Encoding Viral Structural Proteins. PLOS Pathogens 2014, 10: e1004307. PMID: 25166506, PMCID: PMC4148442, DOI: 10.1371/journal.ppat.1004307.Peer-Reviewed Original ResearchMeSH KeywordsBlotting, NorthernGene Expression Regulation, ViralGenetic LociHEK293 CellsHumansProtein Serine-Threonine KinasesReal-Time Polymerase Chain ReactionTransfectionViral ProteinsViral Structural ProteinsVirus ReplicationConceptsLate gene expressionViral DNA replicationLate genesDNA replicationGene expressionOnly protein kinaseEBV transcriptomeDNA tumor virusesPost-replication eventsViral structural proteinsViral structural componentsWild-type Epstein-Barr virusProtein kinaseEctopic expressionKinase geneControl expressionTranscript levelsKinase activityMRNA-seqBGLF4Structural proteinsRegulate expressionGenesControl lociTumor virus
2012
Sex-specific gene expression during asexual development of Neurospora crassa
Wang Z, Kin K, López-Giráldez F, Johannesson H, Townsend JP. Sex-specific gene expression during asexual development of Neurospora crassa. Fungal Genetics And Biology 2012, 49: 533-543. PMID: 22626843, PMCID: PMC3397379, DOI: 10.1016/j.fgb.2012.05.004.Peer-Reviewed Original ResearchConceptsMating-type genesAsexual developmentMating typesNeurospora crassaGene expressionSex-specific gene expressionFungal life historyLight-responsive genesOverall gene expressionExpression levelsDifferent mating typesExpression of pheromonePheromone genesHigh expression levelsMat AType genesLife historyResponse genesExpression differencesDevelopment stagesGenesClonal developmentImpact of lightReceptor geneCrassa