2016
The Epstein-Barr Virus Immunoevasins BCRF1 and BPLF1 Are Expressed by a Mechanism Independent of the Canonical Late Pre-initiation Complex
McKenzie J, Lopez-Giraldez F, Delecluse HJ, Walsh A, El-Guindy A. The Epstein-Barr Virus Immunoevasins BCRF1 and BPLF1 Are Expressed by a Mechanism Independent of the Canonical Late Pre-initiation Complex. PLOS Pathogens 2016, 12: e1006008. PMID: 27855219, PMCID: PMC5113994, DOI: 10.1371/journal.ppat.1006008.Peer-Reviewed Original ResearchMeSH KeywordsBlotting, WesternChromatin ImmunoprecipitationEpstein-Barr Virus InfectionsGene Expression Regulation, ViralGene Knockdown TechniquesHEK293 CellsHerpesvirus 4, HumanHigh-Throughput Nucleotide SequencingHumansImmune EvasionReal-Time Polymerase Chain ReactionViral ProteinsViral Regulatory and Accessory ProteinsViral Structural ProteinsConceptsPre-initiation complexViral pre-initiation complexEpstein-Barr virusLate genesViral gene expressionGene regulatorsViral structural proteinsGene expressionStructural proteinsImmunomodulatory proteinsHost immune surveillanceAntiviral immune responseChIP-seq analysisProtein kinase BGLF4Presence of siRNAsEB virusPrimary infectionImmune surveillanceImmune responseAntiviral drugsImmune evasionGene productsViral pathogenesisBCRF1Gamma herpesvirus
2015
E2F8 as a Novel Therapeutic Target for Lung Cancer
Park SA, Platt J, Lee JW, López-Giráldez F, Herbst RS, Koo JS. E2F8 as a Novel Therapeutic Target for Lung Cancer. Journal Of The National Cancer Institute 2015, 107: djv151. PMID: 26089541, PMCID: PMC4651101, DOI: 10.1093/jnci/djv151.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntineoplastic AgentsCCAAT-Enhancer-Binding ProteinsCell Line, TumorCell ProliferationCell SurvivalChromatin ImmunoprecipitationFluorescent Antibody TechniqueGene Expression Regulation, NeoplasticHumansImmunoblottingKaplan-Meier EstimateLung NeoplasmsMiceMolecular Targeted TherapyNeoplastic Stem CellsPromoter Regions, GeneticRepressor ProteinsTissue Array AnalysisUbiquitin-Protein LigasesUp-RegulationXenograft Model Antitumor AssaysConceptsTarget genesCell cycle regulationNovel therapeutic targetPromoter activity assaysCell proliferationCancer cellsExpression of UHRF1Transcription activatorAntisense morpholinoChromatin immunoprecipitationCycle regulationTherapeutic targetEmbryonic developmentE2F membersHuman lung cancer cellsMicroarray analysisInvasion analysisLung cancer cellsDirect bindingTumor growthE2F8Activity assaysPublic databasesColony formationUHRF1