Microarray analysis of neonatal rat anteroventral periventricular transcriptomes identifies the proapoptotic Cugbp2 gene as sex-specific and regulated by estradiol
Del Pino Sans J, Krishnan S, Aggison LK, Adams HL, Shrikant MM, López-Giráldez F, Petersen SL. Microarray analysis of neonatal rat anteroventral periventricular transcriptomes identifies the proapoptotic Cugbp2 gene as sex-specific and regulated by estradiol. Neuroscience 2015, 303: 312-322. PMID: 26166732, DOI: 10.1016/j.neuroscience.2015.07.008.Peer-Reviewed Original ResearchMeSH KeywordsAnalysis of VarianceAnimalsAnimals, NewbornCELF ProteinsEstradiolFemaleGene Expression Regulation, DevelopmentalHypothalamus, AnteriorMaleNerve Tissue ProteinsOligonucleotide Array Sequence AnalysisPregnancyRatsRats, Sprague-DawleyReceptors, GABAReceptors, GlutamateRNA, MessengerSex DifferentiationTranscriptomeConceptsAnteroventral periventricular nucleusE2-treated femalesPolymerase chain reaction studiesHormone release patternsMetabolites of testosteroneMale anteroventral periventricular nucleusFemale anteroventral periventricular nucleusQuantitative polymerase chain reaction studiesE2 effectsDimorphic neural structuresGender-specific functionsPeriventricular nucleusDimorphic nucleusPerinatal testisHigher mRNA levelsMRNA levelsE2Protein 2Neural structuresSex-specific genesTranslation of mRNAsSex differencesCUG triplet repeatMalesMicroarray analysis