2021
CCM3 Loss-Induced Lymphatic Defect Is Mediated by the Augmented VEGFR3-ERK1/2 Signaling
Qin L, Zhang H, Li B, Jiang Q, Lopez F, Min W, Zhou JH. CCM3 Loss-Induced Lymphatic Defect Is Mediated by the Augmented VEGFR3-ERK1/2 Signaling. Arteriosclerosis Thrombosis And Vascular Biology 2021, 41: 2943-2960. PMID: 34670407, PMCID: PMC8613000, DOI: 10.1161/atvbaha.121.316707.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosis Regulatory ProteinsCells, CulturedEndothelial CellsEndothelium, LymphaticFemaleGene DeletionHemangioma, Cavernous, Central Nervous SystemHyperplasiaMaleMAP Kinase Signaling SystemMice, Inbred StrainsModels, AnimalNF-kappa BTranslocation, GeneticVascular Endothelial Growth Factor Receptor-3ConceptsLymphatic ECsLymphatic defectsCerebral cavernous malformationsPan-endothelial cellsGrowth factor receptorTranscriptional levelTransport assaysLymphatic hyperplasiaCCM genesLymphatic dysfunctionNuclear translocationGenesFactor receptorVEGFR3ERK1/2Nuclear factorDeletionEC proliferationInhibition of VEGFR3Dependent mannerVascular endothelial growth factor receptorEndothelial growth factor receptorEC deletionAbnormal valve structureKPNA2
2005
Phylogenetic inference and comparative evolution of a complex microsatellite and its flanking regions in carnivores
DOMINGO-ROURA X, LÓPEZ-GIRÁLDEZ F, SAEKI M, MARMI J. Phylogenetic inference and comparative evolution of a complex microsatellite and its flanking regions in carnivores. Genetics Research 2005, 85: 223-233. PMID: 16174341, DOI: 10.1017/s0016672305007512.Peer-Reviewed Original ResearchConceptsPhylogenetic inferenceRepetitive motifsFlanking regionsBasal positionNon-coding lociAncestral DNA sequencesShort repetitive motifsHigh mutation rateRepeat additionDNA sequencesCarnivore phylogenyComplex microsatelliteMutational changesCarnivore speciesMutation rateMonotypic familyAilurus fulgensRed pandaMutational hotspotsTree topologyLociRepeat expansionComparative evolutionMeles melesDeletion