2023
Geographic and temporal trends in fentanyl-detected deaths in Connecticut, 2009–2019
Lu H, Crawford F, Gonsalves G, Grau L. Geographic and temporal trends in fentanyl-detected deaths in Connecticut, 2009–2019. Annals Of Epidemiology 2023, 79: 32-38. PMID: 36669599, PMCID: PMC10163838, DOI: 10.1016/j.annepidem.2023.01.009.Peer-Reviewed Original Research
2022
Randomized controlled trials of biomarker targets
Erlendsdottir M, Crawford F. Randomized controlled trials of biomarker targets. Clinical Trials 2022, 20: 47-58. PMID: 36373783, PMCID: PMC9974557, DOI: 10.1177/17407745221131820.Peer-Reviewed Original ResearchConceptsBlood pressure targetsManagement of hypertensionPressure targetsTreatment strategiesBiomarker targetsControlled TrialsRandomized trialsPatient populationLower blood pressure targetsIntensive blood pressure controlAcute respiratory distress syndromePhysicians attemptNew randomized trialsBlood pressure controlRespiratory distress syndromeLack of blindingTrial patient populationValidity of trialsAdaptive treatment strategiesAntihypertensive medicationsAvailable medicationsDistress syndromeTreat analysisTime-varying confoundingTreatment algorithmRandomization for the susceptibility effect of an infectious disease intervention
Eck DJ, Morozova O, Crawford FW. Randomization for the susceptibility effect of an infectious disease intervention. Journal Of Mathematical Biology 2022, 85: 37. PMID: 36127558, PMCID: PMC9809173, DOI: 10.1007/s00285-022-01801-8.Peer-Reviewed Original ResearchConceptsInfectious disease interventionsInfection outcomesInfection riskDisease interventionDirect effectRandomized trialsTreatment allocationInfectious disease transmissionStudy subjectsHarmful treatmentPathogen of interestInterventionOutcomesTreatmentRandomization designVaccineDisease transmissionSusceptibility effectsTrialsRiskRandomizationInfectionIndividualsEvaluating the Mediating Role of Recall of Intervention Knowledge in the Relationship Between a Peer-Driven Intervention and HIV Risk Behaviors Among People Who Inject Drugs
Aroke H, Buchanan A, Katenka N, Crawford FW, Lee T, Halloran ME, Latkin C. Evaluating the Mediating Role of Recall of Intervention Knowledge in the Relationship Between a Peer-Driven Intervention and HIV Risk Behaviors Among People Who Inject Drugs. AIDS And Behavior 2022, 27: 578-590. PMID: 35932359, PMCID: PMC10408304, DOI: 10.1007/s10461-022-03792-5.Peer-Reviewed Original ResearchConceptsInjection-related risk behaviorsPeer-driven interventionRisk behaviorsIntervention knowledgeHIV injection risk behaviorsHIV risk behaviorsInjection risk behaviorsMarginal structural modelsPotential causal pathwaysHIV testingIndex participantsRisk ratioInverse probabilityIntervention NetworkInterventionPeer educatorsTotal effectCausal pathwaysVisitsDrugsFuture studiesParticipantsOutcomesDirect effectPWIDSociodemographic characteristics and HIV risk behaviors of native-born and displaced Syrian men and transgender women who have sex with men in Lebanon
Orr LV, Crawford FW, Khoshnood K, Khouri D, Fouad FM, Seal DW, Heimer R. Sociodemographic characteristics and HIV risk behaviors of native-born and displaced Syrian men and transgender women who have sex with men in Lebanon. AIDS And Behavior 2022, 26: 4004-4011. PMID: 35672550, DOI: 10.1007/s10461-022-03726-1.Peer-Reviewed Original ResearchSARS-CoV-2 Attack Rate and Population Immunity in Southern New England, March 2020 to May 2021
Tran TN, Wikle NB, Yang F, Inam H, Leighow S, Gentilesco B, Chan P, Albert E, Strong ER, Pritchard JR, Hanage WP, Hanks EM, Crawford FW, Boni MF. SARS-CoV-2 Attack Rate and Population Immunity in Southern New England, March 2020 to May 2021. JAMA Network Open 2022, 5: e2214171. PMID: 35616938, PMCID: PMC9136627, DOI: 10.1001/jamanetworkopen.2022.14171.Peer-Reviewed Original ResearchConceptsHigh vaccine coveragePopulation immunityPublic health agenciesVaccine coverageVaccination campaignMAIN OUTCOMECOVID-19 positive test resultsSARS-CoV-2 attack ratesIntensive care unit occupancyHealth agenciesLarge epidemic waveProportion of vaccinesAttack rateObservational case seriesPopulation-level immunitySARS-CoV-2Median ageCase seriesCOVID-19 casesPercentage of individualsVaccination planningDelta variantOngoing epidemicPandemic settingVaccineVaccination with BNT162b2 reduces transmission of SARS-CoV-2 to household contacts in Israel
Prunas O, Warren JL, Crawford FW, Gazit S, Patalon T, Weinberger DM, Pitzer VE. Vaccination with BNT162b2 reduces transmission of SARS-CoV-2 to household contacts in Israel. Science 2022, 375: eabl4292. PMID: 35084937, PMCID: PMC9261115, DOI: 10.1126/science.abl4292.Peer-Reviewed Original ResearchConceptsVaccine effectivenessSevere acute respiratory syndrome coronavirus 2Acute respiratory syndrome coronavirus 2Respiratory syndrome coronavirus 2Syndrome coronavirus 2Effectiveness of vaccinesEffectiveness of vaccinationTotal vaccine effectivenessSARS-CoV-2Household contactsSecond doseCoronavirus 2Household transmissionDelta variantDay 10VaccinationBNT162b2COVID-19InfectionChain binomial modelVaccineDoseImmunity
2021
COVID-19 Testing and Case Rates and Social Contact Among Residential College Students in Connecticut During the 2020-2021 Academic Year
Schultes O, Clarke V, Paltiel AD, Cartter M, Sosa L, Crawford FW. COVID-19 Testing and Case Rates and Social Contact Among Residential College Students in Connecticut During the 2020-2021 Academic Year. JAMA Network Open 2021, 4: e2140602. PMID: 34940864, PMCID: PMC8703252, DOI: 10.1001/jamanetworkopen.2021.40602.Peer-Reviewed Original ResearchConceptsResidential studentsAcademic yearHigher educationResidential college studentsSpring semesterFall semesterStudentsClose interpersonal contactConnecticut CollegeMean contactFall 2020Residential collegeMost institutionsCollege studentsCollegeUniversityCampusSemesterInstitutionsUniversity campusEducationResidence hallsVariety of approachesInterpersonal contactSocial distancing measuresOne year of modeling and forecasting COVID-19 transmission to support policymakers in Connecticut
Morozova O, Li ZR, Crawford FW. One year of modeling and forecasting COVID-19 transmission to support policymakers in Connecticut. Scientific Reports 2021, 11: 20271. PMID: 34642405, PMCID: PMC8511264, DOI: 10.1038/s41598-021-99590-5.Peer-Reviewed Original ResearchConceptsCOVID-19 disease progressionSARS-CoV-2 transmissionCase detection ratioPublic health surveillancePublic health policymakersInfection hospitalizationsCumulative incidenceEpidemiologic featuresClinical progressionCOVID-19 transmissionCOVID-19 projectionsDisease progressionFatality ratioHospital dataEffective reproduction numberHospitalizationHealth surveillanceTransmission riskSEIR-type modelHealth policymakersCOVID-19 epidemicEpidemic trajectoriesDisease transmissionInfectionProgression
2020
Estimates of people who injected drugs within the last 12 months in Belgium based on a capture-recapture and multiplier method
Plettinckx E, Crawford FW, Antoine J, Gremeaux L, Van Baelen L. Estimates of people who injected drugs within the last 12 months in Belgium based on a capture-recapture and multiplier method. Drug And Alcohol Dependence 2020, 219: 108436. PMID: 33310486, PMCID: PMC7856246, DOI: 10.1016/j.drugalcdep.2020.108436.Peer-Reviewed Original ResearchConceptsNew HCV infectionsNumber of PWIDProportion of PWIDLiver-related mortalityEstimates of peopleHarm reduction service providersHCV infectionTreatment registersPWIDNational estimatesCapture-recapture methodologyBaseline dataDrugsNumber of peopleMonthsTotal populationReliable baseline dataSterile needleTotal numberPopulationYearsInfectionMortalityRepeat SARS-CoV-2 testing models for residential college populations
Chang JT, Crawford FW, Kaplan EH. Repeat SARS-CoV-2 testing models for residential college populations. Health Care Management Science 2020, 24: 305-318. PMID: 33200374, PMCID: PMC7669307, DOI: 10.1007/s10729-020-09526-0.Peer-Reviewed Original ResearchEstimation of Excess Deaths Associated With the COVID-19 Pandemic in the United States, March to May 2020
Weinberger DM, Chen J, Cohen T, Crawford FW, Mostashari F, Olson D, Pitzer VE, Reich NG, Russi M, Simonsen L, Watkins A, Viboud C. Estimation of Excess Deaths Associated With the COVID-19 Pandemic in the United States, March to May 2020. JAMA Internal Medicine 2020, 180: 1336-1344. PMID: 32609310, PMCID: PMC7330834, DOI: 10.1001/jamainternmed.2020.3391.Peer-Reviewed Original ResearchConceptsCOVID-19Excess deathsOfficial COVID-19 deathsCoronavirus disease 2019Entire US populationPublic health impactCOVID-19 diagnostic testsCOVID-19 burdenCOVID-19 deathsCause deathReported deathsMortality burdenObservational studyDisease 2019Influenza activityMAIN OUTCOMEDeath AssociatedWeekly deathsTotal deathsUS deathsMore deathsDeath recordsUS populationHealth StatisticsTest availabilityUsing sigLASSO to optimize cancer mutation signatures jointly with sampling likelihood
Li S, Crawford FW, Gerstein MB. Using sigLASSO to optimize cancer mutation signatures jointly with sampling likelihood. Nature Communications 2020, 11: 3575. PMID: 32681003, PMCID: PMC7368050, DOI: 10.1038/s41467-020-17388-x.Peer-Reviewed Original ResearchCreating a Framework for Conducting Randomized Clinical Trials during Disease Outbreaks
Dean NE, Gsell PS, Brookmeyer R, Crawford FW, Donnelly CA, Ellenberg SS, Fleming TR, Halloran ME, Horby P, Jaki T, Krause PR, Longini IM, Mulangu S, Muyembe-Tamfum JJ, Nason MC, Smith PG, Wang R, Henao-Restrepo AM, De Gruttola V. Creating a Framework for Conducting Randomized Clinical Trials during Disease Outbreaks. New England Journal Of Medicine 2020, 382: 1366-1369. PMID: 32242365, PMCID: PMC7490833, DOI: 10.1056/nejmsb1905390.Peer-Reviewed Original ResearchTransmission Modeling with Regression Adjustment for Analyzing Household-based Studies of Infectious Disease: Application to Tuberculosis.
Crawford FW, Marx FM, Zelner J, Cohen T. Transmission Modeling with Regression Adjustment for Analyzing Household-based Studies of Infectious Disease: Application to Tuberculosis. Epidemiology 2020, 31: 238-247. PMID: 31764276, PMCID: PMC7718772, DOI: 10.1097/ede.0000000000001143.Peer-Reviewed Original ResearchConceptsSusceptible household contactsHousehold contactsTB casesBacillus Calmette-Guérin (BCG) vaccinationInfected household contactsIsoniazid preventive therapyActive tuberculosis casesCulture-positive casesRisk of diseaseCohort studyMicrobiological confirmationPreventive therapyTuberculosis casesRisk factorsInfection resultsAdult contactsInfection riskInfectious diseasesLogistic regressionRate of transmissionTransmissible diseasesDiseaseIndividual-level characteristicsHigher hazardDisease susceptibility
2019
Suspected heroin-related overdoses incidents in Cincinnati, Ohio: A spatiotemporal analysis
Li ZR, Xie E, Crawford FW, Warren JL, McConnell K, Copple JT, Johnson T, Gonsalves GS. Suspected heroin-related overdoses incidents in Cincinnati, Ohio: A spatiotemporal analysis. PLOS Medicine 2019, 16: e1002956. PMID: 31714940, PMCID: PMC6850525, DOI: 10.1371/journal.pmed.1002956.Peer-Reviewed Original ResearchConceptsRisk of overdoseRisk of incidentBlock groupHarm reduction measuresPoisson regression modelsHighest overdose ratesOpioid misuseRisk factorsOpioid epidemicOpiate overdosesOverdose incidentsOpioid overdosesOverdose ratesNature of incidentsEmergency callsMale populationMedian household incomeTreatment programOverdose emergencyHealth policySpatiotemporal risk factorsLack of informationDemographic characteristicsHigher numberOverdosesCost‐effectiveness of expanding the capacity of opioid agonist treatment in Ukraine: dynamic modeling analysis
Morozova O, Crawford FW, Cohen T, Paltiel AD, Altice FL. Cost‐effectiveness of expanding the capacity of opioid agonist treatment in Ukraine: dynamic modeling analysis. Addiction 2019, 115: 437-450. PMID: 31478285, PMCID: PMC7015766, DOI: 10.1111/add.14797.Peer-Reviewed Original ResearchConceptsOpioid agonist treatmentOpioid use disorderOAT coverageAgonist treatmentGross domestic productOpioid use initiationOpioid addiction epidemicOAT accessHIV epidemicUse disordersAddiction epidemicCapita gross domestic productPay thresholdsTreatment demandUse initiationAddiction treatmentIncremental costBaseline capacityTreatmentPotential peer effectsDomestic productTreatment spilloversEpidemicPeer effectsCoverage levelsViolence and Discrimination Against Men Who Have Sex With Men in Lebanon: The Role of International Displacement and Migration
Orr L, Shebl FM, Heimer R, Khoshnood K, Barbour R, Khouri D, Aaraj E, Mokhbat JE, Crawford FW. Violence and Discrimination Against Men Who Have Sex With Men in Lebanon: The Role of International Displacement and Migration. Journal Of Interpersonal Violence 2019, 36: 10267-10284. PMID: 31658847, DOI: 10.1177/0886260519884684.Peer-Reviewed Original ResearchConceptsExperiences of violenceLocal nongovernmental organizationsFramework of intersectionalityInternational displacementNongovernmental organizationsViolenceLebanonLebanon’s populationNetwork analysisGeographical mappingExperienceHeightened levelsIntersectionalityDiscriminationSyriansHomosexualityPartnershipSyriaAnonymous HIV testingHealth behavior surveyBehavior SurveySocioeconomic statusMenCommunityBeirutDivergent estimates of HIV incidence among people who inject drugs in Ukraine
Morozova O, Booth RE, Dvoriak S, Dumchev K, Sazonova Y, Saliuk T, Crawford FW. Divergent estimates of HIV incidence among people who inject drugs in Ukraine. International Journal Of Drug Policy 2019, 73: 156-162. PMID: 31405731, PMCID: PMC6899203, DOI: 10.1016/j.drugpo.2019.07.023.Peer-Reviewed Original ResearchConceptsHIV incidenceStudy subjectsBio-behavioral surveillance surveysRecent syringe sharingPopulation of PWIDLongitudinal cohort studyDrug of choiceLow-risk individualsCross-sectional surveyBaseline characteristicsCohort studyAverage monthly numberRisk stratificationSyringe sharingIntervention trialsSurveillance SurveyHigh incidenceRisk individualsRCTsPWIDStudy designIncidenceDrugsFuture surveillanceSignificant differencesEmpirical evidence of recruitment bias in a network study of people who inject drugs
Zeng L, Li J, Crawford FW. Empirical evidence of recruitment bias in a network study of people who inject drugs. The American Journal Of Drug And Alcohol Abuse 2019, 45: 460-469. PMID: 30896982, PMCID: PMC7680667, DOI: 10.1080/00952990.2019.1584203.Peer-Reviewed Original Research