2022
Vaccination with BNT162b2 reduces transmission of SARS-CoV-2 to household contacts in Israel
Prunas O, Warren JL, Crawford FW, Gazit S, Patalon T, Weinberger DM, Pitzer VE. Vaccination with BNT162b2 reduces transmission of SARS-CoV-2 to household contacts in Israel. Science 2022, 375: eabl4292. PMID: 35084937, PMCID: PMC9261115, DOI: 10.1126/science.abl4292.Peer-Reviewed Original ResearchConceptsVaccine effectivenessSevere acute respiratory syndrome coronavirus 2Acute respiratory syndrome coronavirus 2Respiratory syndrome coronavirus 2Syndrome coronavirus 2Effectiveness of vaccinesEffectiveness of vaccinationTotal vaccine effectivenessSARS-CoV-2Household contactsSecond doseCoronavirus 2Household transmissionDelta variantDay 10VaccinationBNT162b2COVID-19InfectionChain binomial modelVaccineDoseImmunity
2020
Transmission Modeling with Regression Adjustment for Analyzing Household-based Studies of Infectious Disease: Application to Tuberculosis.
Crawford FW, Marx FM, Zelner J, Cohen T. Transmission Modeling with Regression Adjustment for Analyzing Household-based Studies of Infectious Disease: Application to Tuberculosis. Epidemiology 2020, 31: 238-247. PMID: 31764276, PMCID: PMC7718772, DOI: 10.1097/ede.0000000000001143.Peer-Reviewed Original ResearchConceptsSusceptible household contactsHousehold contactsTB casesBacillus Calmette-Guérin (BCG) vaccinationInfected household contactsIsoniazid preventive therapyActive tuberculosis casesCulture-positive casesRisk of diseaseCohort studyMicrobiological confirmationPreventive therapyTuberculosis casesRisk factorsInfection resultsAdult contactsInfection riskInfectious diseasesLogistic regressionRate of transmissionTransmissible diseasesDiseaseIndividual-level characteristicsHigher hazardDisease susceptibility
2015
Obesity not associated with severity among hospitalized adults with seasonal influenza virus infection
Braun ES, Crawford FW, Desai MM, Meek J, Kirley PD, Miller L, Anderson EJ, Oni O, Ryan P, Lynfield R, Bargsten M, Bennett NM, Lung KL, Thomas A, Mermel E, Lindegren ML, Schaffner W, Price A, Chaves SS. Obesity not associated with severity among hospitalized adults with seasonal influenza virus infection. Infection 2015, 43: 569-575. PMID: 26148927, DOI: 10.1007/s15010-015-0802-x.Peer-Reviewed Original ResearchConceptsSeasonal influenza virus infectionMultivariate logistic regression modelSeasonal influenza severityLaboratory-confirmed influenzaRisk of pneumoniaInfluenza virus infectionLogistic regression modelsHospitalized adultsICU admissionObese patientsSevere obesityInfluenza severityArtificial ventilationVirus infectionWeight categoriesObesityPneumoniaSeverityRegression modelsAdultsUnderweightPatientsAdmissionInfectionInfluenza
2008
Relationship of pre-surgery metabolic and physiological MR imaging parameters to survival for patients with untreated GBM
Crawford FW, Khayal IS, McGue C, Saraswathy S, Pirzkall A, Cha S, Lamborn KR, Chang SM, Berger MS, Nelson SJ. Relationship of pre-surgery metabolic and physiological MR imaging parameters to survival for patients with untreated GBM. Journal Of Neuro-Oncology 2008, 91: 337. PMID: 19009235, PMCID: PMC3022444, DOI: 10.1007/s11060-008-9719-x.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAspartic AcidBrain MappingBrain NeoplasmsCholineCreatineDiagnosis, DifferentialDiffusion Magnetic Resonance ImagingFemaleGlioblastomaHumansImage EnhancementImage Processing, Computer-AssistedKaplan-Meier EstimateLactic AcidLipidsMagnetic Resonance ImagingMagnetic Resonance SpectroscopyMaleMiddle AgedProtonsRadionuclide ImagingRetrospective StudiesConceptsGlioblastoma multiformeApparent diffusion coefficientPoor survivalConventional anatomical MR imagingAnatomical MR imagingUntreated glioblastoma multiformeT2 hyperintense lesionsMedian survival timeLow-risk groupBlood-brain barrierStratification of patientsContrast-enhancing lesionsPerfusion-weighted imagingDiffusion-weighted imagingPhysiological MRProton MR spectroscopicFavorable survivalSurgical resectionT2 lesionsHyperintense lesionsPrognostic valueBrain barrierElevated cholineClinical trialsLesion volumeEvaluation of MR markers that predict survival in patients with newly diagnosed GBM prior to adjuvant therapy
Saraswathy S, Crawford FW, Lamborn KR, Pirzkall A, Chang S, Cha S, Nelson SJ. Evaluation of MR markers that predict survival in patients with newly diagnosed GBM prior to adjuvant therapy. Journal Of Neuro-Oncology 2008, 91: 69-81. PMID: 18810326, PMCID: PMC3022437, DOI: 10.1007/s11060-008-9685-3.Peer-Reviewed Original ResearchConceptsGlioblastoma multiformeRadiation therapyExternal beam radiation therapyLethal primary brain tumorProportional hazards analysisSurvival of patientsPrimary brain tumorsSpecific treatment protocolsBeam radiation therapyAdjuvant radiationAdjuvant therapySurgical resectionLesion burdenMR parametersPoor outcomeAnatomic lesionsPoor survivalScanner field strengthTreatment protocolStudy populationFocal therapyHigh riskBrain tumorsPatientsPredictive valueRelationship between choline and apparent diffusion coefficient in patients with gliomas
Khayal IS, Crawford FW, Saraswathy S, Lamborn KR, Chang SM, Cha S, McKnight TR, Nelson SJ. Relationship between choline and apparent diffusion coefficient in patients with gliomas. Journal Of Magnetic Resonance Imaging 2008, 27: 718-725. PMID: 18383265, PMCID: PMC3030277, DOI: 10.1002/jmri.21288.Peer-Reviewed Original Research
2005
Differentiation of low-grade oligodendrogliomas from low-grade astrocytomas by using quantitative blood-volume measurements derived from dynamic susceptibility contrast-enhanced MR imaging.
Cha S, Tihan T, Crawford F, Fischbein NJ, Chang S, Bollen A, Nelson SJ, Prados M, Berger MS, Dillon WP. Differentiation of low-grade oligodendrogliomas from low-grade astrocytomas by using quantitative blood-volume measurements derived from dynamic susceptibility contrast-enhanced MR imaging. American Journal Of Neuroradiology 2005, 26: 266-73. PMID: 15709123, PMCID: PMC7974081.Peer-Reviewed Original ResearchConceptsBlood volume measurementsDSC-MR imagingLow-grade oligodendrogliomasMR imagingWorld Health Organization grade II astrocytomaGrade II astrocytomasContrast-enhanced MR imagingCerebral blood volume measurementsLow-grade astrocytomasContrast-enhanced MRLow-grade gliomasSpecific tumor markersDynamic susceptibility contrast-enhanced MR imagingMaximum relative CBVDiagnosis of gliomaSurgical resectionConsecutive patientsHistologic confirmationHistologic subtypeCommon subtypeHistopathologic evaluationMorphologic aberrationsTumor vascularityTumor markersAnatomic imaging