Randomized controlled trials of biomarker targets
Erlendsdottir M, Crawford F. Randomized controlled trials of biomarker targets. Clinical Trials 2022, 20: 47-58. PMID: 36373783, PMCID: PMC9974557, DOI: 10.1177/17407745221131820.Peer-Reviewed Original ResearchConceptsBlood pressure targetsManagement of hypertensionPressure targetsTreatment strategiesBiomarker targetsControlled TrialsRandomized trialsPatient populationLower blood pressure targetsIntensive blood pressure controlAcute respiratory distress syndromePhysicians attemptNew randomized trialsBlood pressure controlRespiratory distress syndromeLack of blindingTrial patient populationValidity of trialsAdaptive treatment strategiesAntihypertensive medicationsAvailable medicationsDistress syndromeTreat analysisTime-varying confoundingTreatment algorithmRandomization for the susceptibility effect of an infectious disease intervention
Eck DJ, Morozova O, Crawford FW. Randomization for the susceptibility effect of an infectious disease intervention. Journal Of Mathematical Biology 2022, 85: 37. PMID: 36127558, PMCID: PMC9809173, DOI: 10.1007/s00285-022-01801-8.Peer-Reviewed Original ResearchConceptsInfectious disease interventionsInfection outcomesInfection riskDisease interventionDirect effectRandomized trialsTreatment allocationInfectious disease transmissionStudy subjectsHarmful treatmentPathogen of interestInterventionOutcomesTreatmentRandomization designVaccineDisease transmissionSusceptibility effectsTrialsRiskRandomizationInfectionIndividuals