Differential induction of immediate early genes by excitatory amino acid receptor types in primary cultures of cortical and striatal neurons
Vaccarino F, Hayward M, Nestler E, Duman R, Tallman J. Differential induction of immediate early genes by excitatory amino acid receptor types in primary cultures of cortical and striatal neurons. Brain Research 1992, 12: 233-241. PMID: 1347632, DOI: 10.1016/0169-328x(92)90089-t.Peer-Reviewed Original ResearchMeSH Keywords1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine6-Cyano-7-nitroquinoxaline-2,3-dioneAnimalsAnimals, NewbornBlotting, NorthernCells, CulturedCerebral CortexCorpus StriatumDNA-Binding ProteinsEarly Growth Response Protein 1Gene Expression RegulationGenes, fosGenes, junGenes, RegulatorGlutamatesGlutamic AcidGlycineImmediate-Early ProteinsIsoquinolinesNeuronsPiperazinesProtein Kinase InhibitorsProto-OncogenesQuinoxalinesQuisqualic AcidRatsReceptors, AMPAReceptors, NeurotransmitterReceptors, N-Methyl-D-AspartateRNA, MessengerSulfonamidesTranscription FactorsConceptsProtein kinase C inhibitor HNGFI-A mRNAC-fosImmediate early genesPrimary culturesC-JunEarly genesGene mRNAN-methyl-D-aspartate receptor typeExcitatory amino acid receptor typesReceptor typesInhibitor HHydroxy-5-methylisoxazolepropionic acidExcitatory amino acid glutamateIEG expressionTransmembrane calcium influxDifferential inductionNMDA receptor channelsNMDA receptor activationAmino acid glutamateMRNAReceptor activationImmediate early gene mRNAsReceptor channelsCerebral cortex