2014
Fgfr1 Inactivation in the Mouse Telencephalon Results in Impaired Maturation of Interneurons Expressing Parvalbumin
Smith KM, Maragnoli ME, Phull PM, Tran KM, Choubey L, Vaccarino FM. Fgfr1 Inactivation in the Mouse Telencephalon Results in Impaired Maturation of Interneurons Expressing Parvalbumin. PLOS ONE 2014, 9: e103696. PMID: 25116473, PMCID: PMC4130531, DOI: 10.1371/journal.pone.0103696.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisAstrocytesCell CommunicationCell CountCell MovementCell ProliferationCoculture TechniquesGene DeletionGene ExpressionGene SilencingInterneuronsMiceMice, TransgenicMutationParvalbuminsReceptor, Fibroblast Growth Factor, Type 1TelencephalonConceptsGanglionic eminenceSoma sizeCortical interneuronsAstrocytes of miceCortex of adultCortical GABAergic neuronsParvalbumin-positive cortical interneuronsRadial glial cellsSmaller soma sizeMedial ganglionic eminenceFibroblast growth factorDeficient astrocytesLocomotor hyperactivityGABAergic cellsGABAergic neuronsInterneuron maturationGlial cellsCortical astrocytesPostnatal periodAdult CNSPostnatal brainInterneuron markersInterneuronsImmunopositive interneuronsAstrocytes
2012
Impaired motor coordination and disrupted cerebellar architecture in Fgfr1 and Fgfr2 double knockout mice
Smith K, Williamson TL, Schwartz ML, Vaccarino FM. Impaired motor coordination and disrupted cerebellar architecture in Fgfr1 and Fgfr2 double knockout mice. Brain Research 2012, 1460: 12-24. PMID: 22578469, PMCID: PMC3361544, DOI: 10.1016/j.brainres.2012.04.002.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCerebellar DiseasesFemaleHumansMaleMiceMice, KnockoutMice, Neurologic MutantsMotor Skills DisordersReceptor, Fibroblast Growth Factor, Type 1Receptor, Fibroblast Growth Factor, Type 2ConceptsFibroblast growth factor receptorHuman GFAP promoterInner granule cell layerDKO miceGranule cell numberGranule cell progenitorsRadial glial stem cellsMidline glial structuresImpaired motor coordinationCerebellar sizeGranule cell layerDouble knockout miceGlial precursor cellsGlial stem cellsCell numberGranule neuron precursorsGrowth factor receptorGABA interneuronsGranule cell migrationCerebral cortexExternal granular layerMolecular layerMotor coordinationGranule cellsKnockout mice
2009
Fgfr1 Is Required for Cortical Regeneration and Repair after Perinatal Hypoxia
Fagel DM, Ganat Y, Cheng E, Silbereis J, Ohkubo Y, Ment LR, Vaccarino FM. Fgfr1 Is Required for Cortical Regeneration and Repair after Perinatal Hypoxia. Journal Of Neuroscience 2009, 29: 1202-1211. PMID: 19176828, PMCID: PMC2768410, DOI: 10.1523/jneurosci.4516-08.2009.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAnalysis of VarianceAnimalsAnimals, NewbornBromodeoxyuridineCell ProliferationCerebral CortexCreatinineDNA-Binding ProteinsGlial Fibrillary Acidic ProteinHypoxiaMiceMice, Inbred C57BLMice, TransgenicNerve RegenerationNeurogenesisNeuronsOlfactory BulbParvalbuminsPhosphopyruvate HydrataseReceptor, Fibroblast Growth Factor, Type 1T-Box Domain ProteinsConceptsWild-type miceCortical neuronsOlfactory bulbSubventricular zoneChronic postnatal hypoxiaNeonatal hypoxic injuryPersistent behavioral deficitsExcitatory cortical neuronsSVZ cell proliferationCell proliferationPostnatal day 3Receptor 1 geneNormoxic miceOB neurogenesisReactive neurogenesisPerinatal hypoxiaPostnatal hypoxiaNeuronal recoveryFibroblast growth factor receptor 1 (FGFR1) geneHypoxic miceChronic hypoxiaGABAergic interneuronsHypoxic injuryResidual deficitsCortical regeneration
2006
Midline radial glia translocation and corpus callosum formation require FGF signaling
Smith KM, Ohkubo Y, Maragnoli ME, Rašin M, Schwartz ML, Šestan N, Vaccarino FM. Midline radial glia translocation and corpus callosum formation require FGF signaling. Nature Neuroscience 2006, 9: 787-797. PMID: 16715082, DOI: 10.1038/nn1705.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAstrocytesCell MovementCell ShapeCerebral CortexCorpus CallosumDown-RegulationFemaleFibroblast Growth Factor 8Fibroblast Growth FactorsGrowth ConesMaleMiceMice, KnockoutMice, TransgenicNeurogliaReceptor, Fibroblast Growth Factor, Type 1Receptor, Fibroblast Growth Factor, Type 2RNA InterferenceSignal TransductionConceptsRadial glial cellsGlial cellsSomal translocationRadial gliaCorpus callosum formationReceptor 1 geneCallosal dysgenesisCerebral cortexFibroblast growth factor receptor 1 (FGFR1) geneIndusium griseumDorsomedial cortexDorsolateral cortexKnockout miceCortexAstrogliaApical endfeetFGFR1 geneAstrocytesGliaAxon guidanceDorsal midlinePrecise targetingCellsUnexpected roleFGF
2004
Fibroblast Growth Factor Receptor 1 Is Required for the Proliferation of Hippocampal Progenitor Cells and for Hippocampal Growth in Mouse
Ohkubo Y, Uchida AO, Shin D, Partanen J, Vaccarino FM. Fibroblast Growth Factor Receptor 1 Is Required for the Proliferation of Hippocampal Progenitor Cells and for Hippocampal Growth in Mouse. Journal Of Neuroscience 2004, 24: 6057-6069. PMID: 15240797, PMCID: PMC6729672, DOI: 10.1523/jneurosci.1140-04.2004.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, DifferentiationCell CountCell LineageCell ProliferationCells, CulturedHeredodegenerative Disorders, Nervous SystemHippocampusHumansIn Situ HybridizationLateral VentriclesMiceMice, TransgenicMutagenesis, Site-DirectedNeurogliaNeuronsPyramidal CellsReceptor Protein-Tyrosine KinasesReceptor, Fibroblast Growth Factor, Type 1Receptors, Fibroblast Growth FactorRNA, MessengerStem CellsTransgenesConceptsHippocampal ventricular zonesDentate gyrusGrowth factor receptor 1Fibroblast growth factor receptor 1Factor receptor 1Ventricular zoneNeural stem cellsPyramidal neuronsHippocampal growthProgenitor cellsGranule cellsReceptor 1Glial fibrillary acidic protein promoterHuman glial fibrillary acidic protein promoterEmbryonic dorsal telencephalonRadial glial-like cellsRadial glial progenitor cellsHippocampal dentate gyrusParvalbumin-containing interneuronsDG granule cellsHippocampal pyramidal neuronsStem cellsHippocampal progenitor cellsRole of FGFR1Glial progenitor cellsLoss of Glutamatergic Pyramidal Neurons in Frontal and Temporal Cortex Resulting from Attenuation of FGFR1 Signaling Is Associated with Spontaneous Hyperactivity in Mice
Shin DM, Korada S, Raballo R, Shashikant CS, Simeone A, Taylor JR, Vaccarino F. Loss of Glutamatergic Pyramidal Neurons in Frontal and Temporal Cortex Resulting from Attenuation of FGFR1 Signaling Is Associated with Spontaneous Hyperactivity in Mice. Journal Of Neuroscience 2004, 24: 2247-2258. PMID: 14999075, PMCID: PMC6730438, DOI: 10.1523/jneurosci.5285-03.2004.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic alpha-AgonistsAmphetamineAnimalsCell DifferentiationCell DivisionFrontal LobeGlutamic AcidGuanfacineHumansHyperkinesisMiceMice, TransgenicNervous System MalformationsNeural InhibitionPyramidal CellsReceptor Protein-Tyrosine KinasesReceptor, Fibroblast Growth Factor, Type 1Receptors, Adrenergic, alpha-2Receptors, Fibroblast Growth FactorSignal TransductionStereotypic Movement DisorderTemporal LobeConceptsPyramidal neuronsCortical developmentTemporal areaSubcortical monoaminergic systemsGlutamatergic pyramidal neuronsCajal-Retzius cellsCortical GABAergic interneuronsCerebral cortical developmentAdrenergic receptor agonistEmbryonic neural progenitor cellsTemporal cortical areasReceptor gene productsNeural progenitor cellsEmbryonic brain developmentLocomotor hyperactivityRadial glia fibersCerebral cortexGlutamatergic neuronsBasal gangliaGABAergic interneuronsMonoaminergic systemsCortical plateReceptor agonistSpontaneous hyperactivityCortical areas
2002
Chronic hypoxia up-regulates fibroblast growth factor ligands in the perinatal brain and induces fibroblast growth factor-responsive radial glial cells in the sub-ependymal zone
Ganat Y, Soni S, Chacon M, Schwartz ML, Vaccarino FM. Chronic hypoxia up-regulates fibroblast growth factor ligands in the perinatal brain and induces fibroblast growth factor-responsive radial glial cells in the sub-ependymal zone. Neuroscience 2002, 112: 977-991. PMID: 12088755, DOI: 10.1016/s0306-4522(02)00060-x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlotting, WesternCerebral CortexCerebral VentriclesEnzyme-Linked Immunosorbent AssayEpendymaFibroblast Growth Factor 1Fibroblast Growth Factor 2HypoxiaImmunohistochemistryNeurogliaRatsReceptor Protein-Tyrosine KinasesReceptor, Fibroblast Growth Factor, Type 1Receptor, Fibroblast Growth Factor, Type 2Receptors, Fibroblast Growth FactorRegenerationUp-RegulationConceptsRadial glial cellsRadial gliaChronic hypoxiaGlial cellsFibroblast growth factor 1Periventricular regionBrain lipid binding proteinMajor receptorChronic hypoxic damageGlial fibrillary acidic proteinHypoxia/ischemiaSub-ventricular zoneImmature glial cellsFibrillary acidic proteinGrowth factor-1Ependymal zoneChronic hypoxemiaCerebral cortexHypoxic damageNeurotrophin familyPerinatal brainFGF receptor 1Rat pupsPostnatal weekGlial phenotype
2000
Basic Fibroblast Growth Factor (Fgf2) Is Necessary for Cell Proliferation and Neurogenesis in the Developing Cerebral Cortex
Raballo R, Rhee J, Lyn-Cook R, Leckman J, Schwartz M, Vaccarino F. Basic Fibroblast Growth Factor (Fgf2) Is Necessary for Cell Proliferation and Neurogenesis in the Developing Cerebral Cortex. Journal Of Neuroscience 2000, 20: 5012-5023. PMID: 10864959, PMCID: PMC6772267, DOI: 10.1523/jneurosci.20-13-05012.2000.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisCell DivisionCerebral CortexChoroid PlexusEmbryonic and Fetal DevelopmentFibroblast Growth Factor 2Gene Expression Regulation, DevelopmentalGerm-Line MutationGestational AgeMiceMice, KnockoutProsencephalonReceptor Protein-Tyrosine KinasesReceptor, Fibroblast Growth Factor, Type 1Receptors, Fibroblast Growth FactorTelencephalonConceptsFgf2 knockout micePseudostratified ventricular epitheliumKnockout miceCerebral cortexCortical neuronsFrontal cerebral cortexDeep cortical layersBasic fibroblast growth factorEnd of neurogenesisCortical neuron numberNeuronal progenitor cellsNull mutant miceBasic fibroblast growth factor (bFGF) geneFibroblast growth factorDegree of apoptosisLarge neuronsBasal gangliaCortical layersFgf2 knockoutGrowth factor geneMutant miceVentricular epitheliumGermline mutationsNeuron numberNeurogenesis