2016
Altering the course of schizophrenia: progress and perspectives
Millan MJ, Andrieux A, Bartzokis G, Cadenhead K, Dazzan P, Fusar-Poli P, Gallinat J, Giedd J, Grayson DR, Heinrichs M, Kahn R, Krebs MO, Leboyer M, Lewis D, Marin O, Marin P, Meyer-Lindenberg A, McGorry P, McGuire P, Owen MJ, Patterson P, Sawa A, Spedding M, Uhlhaas P, Vaccarino F, Wahlestedt C, Weinberger D. Altering the course of schizophrenia: progress and perspectives. Nature Reviews Drug Discovery 2016, 15: 485-515. PMID: 26939910, DOI: 10.1038/nrd.2016.28.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsCourse of schizophreniaCognitive-behavioral interventionsSocial deficitsSchizophrenia-like phenotypeCognitive deficitsCausal pathophysiologyYoung adulthoodYoung adultsPrediction of transitionBrain imagingKey PointsSchizophreniaLevel of individualsHigh-risk individualsSchizophreniaVulnerable young adultsDeficitsPsychosisIndividualsAdult rodentsRisk individualsPharmacological treatmentDisordersAdolescenceUse of biomarkersDistress
2008
Regulation of Cerebral Cortical Size and Neuron Number by Fibroblast Growth Factors: Implications for Autism
Vaccarino FM, Grigorenko EL, Smith KM, Stevens HE. Regulation of Cerebral Cortical Size and Neuron Number by Fibroblast Growth Factors: Implications for Autism. Journal Of Autism And Developmental Disorders 2008, 39: 511-520. PMID: 18850329, PMCID: PMC2847619, DOI: 10.1007/s10803-008-0653-8.Peer-Reviewed Original ResearchConceptsFibroblast growth factorCortical sizeNeuron numberExcitatory/inhibitory balanceGrowth factorCortical excitatory neuronsCortical neuron numberCerebral cortical sizeAutism spectrum disorderNetwork excitabilityInhibitory balanceRisk factorsCortical volumePathogenetic pathwaysExcitatory neuronsSpectrum disorderAnimal modelsBrain volumeDevelopmental alterationsPathologyDisordersSocial deficitsBrain sizeFGF genesSeizures