2023
Author Correction: Modeling idiopathic autism in forebrain organoids reveals an imbalance of excitatory cortical neuron subtypes during early neurogenesis
Jourdon A, Wu F, Mariani J, Capauto D, Norton S, Tomasini L, Amiri A, Suvakov M, Schreiner J, Jang Y, Panda A, Nguyen C, Cummings E, Han G, Powell K, Szekely A, McPartland J, Pelphrey K, Chawarska K, Ventola P, Abyzov A, Vaccarino F. Author Correction: Modeling idiopathic autism in forebrain organoids reveals an imbalance of excitatory cortical neuron subtypes during early neurogenesis. Nature Neuroscience 2023, 26: 2035-2035. PMID: 37674007, DOI: 10.1038/s41593-023-01447-9.Peer-Reviewed Original Research
2017
Different mutational rates and mechanisms in human cells at pregastrulation and neurogenesis
Bae T, Tomasini L, Mariani J, Zhou B, Roychowdhury T, Franjic D, Pletikos M, Pattni R, Chen BJ, Venturini E, Riley-Gillis B, Sestan N, Urban AE, Abyzov A, Vaccarino FM. Different mutational rates and mechanisms in human cells at pregastrulation and neurogenesis. Science 2017, 359: 550-555. PMID: 29217587, PMCID: PMC6311130, DOI: 10.1126/science.aan8690.Peer-Reviewed Original ResearchConceptsSingle nucleotide variationsMutation rateCancer cell genomeClonal cell populationsCell genomeCell lineagesBackground mutagenesisHuman cellsMutational rateSomatic mosaicismSingle cellsOxidative damageGenomeMutagenesisCell populationsMutation spectrumNeurogenesisCellsHuman fetusesIndividual neuronsLineagesPregastrulationHuman brainBrainMutations
2013
Cortical Gyrification Induced by Fibroblast Growth Factor 2 in the Mouse Brain
Rash BG, Tomasi S, Lim HD, Suh CY, Vaccarino FM. Cortical Gyrification Induced by Fibroblast Growth Factor 2 in the Mouse Brain. Journal Of Neuroscience 2013, 33: 10802-10814. PMID: 23804101, PMCID: PMC3693057, DOI: 10.1523/jneurosci.3621-12.2013.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntimetabolitesAxonsBrain ChemistryBromodeoxyuridineCell CountCerebral CortexCerebral VentriclesDensitometryDependovirusDNA, ComplementaryFemaleFibroblast Growth Factor 2Green Fluorescent ProteinsImmunohistochemistryIn Situ HybridizationLymphoid Enhancer-Binding Factor 1MiceNeocortexPregnancyReal-Time Polymerase Chain ReactionRNAWnt3A ProteinConceptsVentricular zoneIntermediate neuronal progenitorsSubventricular zoneCortical gyrificationCortical primordiumRegion-specific actionsFibroblast growth factor-2ER81 expressionGrowth factor 2Ventricular injectionCortical layer structureBasal radial gliaCortical gyriRadial gliaMouse brainCortical hemEmbryonic day 11.5Neuronal progenitorsGyrus formationLEF1 expressionGyrificationNeurogenesisLissencephalic speciesFactor 2Impaired growth
2011
FGF Signaling Expands Embryonic Cortical Surface Area by Regulating Notch-Dependent Neurogenesis
Rash BG, Lim HD, Breunig JJ, Vaccarino FM. FGF Signaling Expands Embryonic Cortical Surface Area by Regulating Notch-Dependent Neurogenesis. Journal Of Neuroscience 2011, 31: 15604-15617. PMID: 22031906, PMCID: PMC3235689, DOI: 10.1523/jneurosci.4439-11.2011.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAnalysis of VarianceAnimalsBrainBromodeoxyuridineCaspase 3Cell CountCell DifferentiationCells, CulturedCerebral CortexDNA-Binding ProteinsElectroporationEmbryo, MammalianEye ProteinsFatty Acid-Binding Protein 7Fatty Acid-Binding ProteinsFibroblast Growth FactorsGene Expression Regulation, DevelopmentalGreen Fluorescent ProteinsHomeodomain ProteinsKi-67 AntigenMiceMice, TransgenicMutationNerve Tissue ProteinsNeurogenesisNeuronsPaired Box Transcription FactorsPAX6 Transcription FactorReceptors, Fibroblast Growth FactorReceptors, NotchRepressor ProteinsSignal TransductionStem CellsT-Box Domain ProteinsTranscription FactorsConceptsCortical neurogenesisCortical surface area expansionCortical surface expansionCortical surface areaGrowth factor receptorEmbryonic day 12.5Fibroblast growth factor receptorFGFR mutantsNormal miceCortical layer structureCortical developmentNeurogenic stagesDominant negative FGFRLoss of functionRadial progenitorsNeurogenesisNotch pathway genesSevere deficitsFactor receptorDay 12.5Notch pathwayMiceSimultaneous activationGreater proportionFGFR activity
2000
Basic Fibroblast Growth Factor (Fgf2) Is Necessary for Cell Proliferation and Neurogenesis in the Developing Cerebral Cortex
Raballo R, Rhee J, Lyn-Cook R, Leckman J, Schwartz M, Vaccarino F. Basic Fibroblast Growth Factor (Fgf2) Is Necessary for Cell Proliferation and Neurogenesis in the Developing Cerebral Cortex. Journal Of Neuroscience 2000, 20: 5012-5023. PMID: 10864959, PMCID: PMC6772267, DOI: 10.1523/jneurosci.20-13-05012.2000.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisCell DivisionCerebral CortexChoroid PlexusEmbryonic and Fetal DevelopmentFibroblast Growth Factor 2Gene Expression Regulation, DevelopmentalGerm-Line MutationGestational AgeMiceMice, KnockoutProsencephalonReceptor Protein-Tyrosine KinasesReceptor, Fibroblast Growth Factor, Type 1Receptors, Fibroblast Growth FactorTelencephalonConceptsFgf2 knockout micePseudostratified ventricular epitheliumKnockout miceCerebral cortexCortical neuronsFrontal cerebral cortexDeep cortical layersBasic fibroblast growth factorEnd of neurogenesisCortical neuron numberNeuronal progenitor cellsNull mutant miceBasic fibroblast growth factor (bFGF) geneFibroblast growth factorDegree of apoptosisLarge neuronsBasal gangliaCortical layersFgf2 knockoutGrowth factor geneMutant miceVentricular epitheliumGermline mutationsNeuron numberNeurogenesis
1999
Changes in cerebral cortex size are governed by fibroblast growth factor during embryogenesis
Vaccarino F, Schwartz M, Raballo R, Nilsen J, Rhee J, Zhou M, Doetschman T, Coffin J, Wyland J, Hung Y. Changes in cerebral cortex size are governed by fibroblast growth factor during embryogenesis. Nature Neuroscience 1999, 2: 246-253. PMID: 10195217, DOI: 10.1038/6350.Peer-Reviewed Original ResearchConceptsPseudostratified ventricular epitheliumFibroblast growth factor-2Number of gliaAdult cerebral cortexEnd of neurogenesisCerebral cortex sizeFibroblast growth factorGrowth factor 2Cerebral cortexCerebral ventricleSingle microinjectionCortical neuronsBrdU studiesCortical progenitorsVentricular epitheliumCortex sizeGrowth factorRat embryosFGF2 geneEarly neurogenesisFGF receptorsFactor 2GliaNeurogenesisCell cycle length