2012
Learning and Memory Depend on Fibroblast Growth Factor Receptor 2 Functioning in Hippocampus
Stevens HE, Jiang GY, Schwartz ML, Vaccarino FM. Learning and Memory Depend on Fibroblast Growth Factor Receptor 2 Functioning in Hippocampus. Biological Psychiatry 2012, 71: 1090-1098. PMID: 22541947, PMCID: PMC3371339, DOI: 10.1016/j.biopsych.2012.03.013.Peer-Reviewed Original ResearchConceptsFGF receptor 2Fibroblast growth factorDentate gyrusReceptor 2Embryonic knockoutWater maze probe trialGrowth factor receptor 2Reference memoryFactor receptor 2Spatial reference memoryNeural stem cellsFibroblast growth factor receptor 2Immature neuronsCortical neuronsHippocampal volumeInducible knockout miceParvalbumin interneuronsShort-term learningGranule cellsKnockout miceSeparate cellular componentsHippocampusLong-term reference memoryAdult spatial memoryGrowth factor
2010
Neural Stem Cell Regulation, Fibroblast Growth Factors, and the Developmental Origins of Neuropsychiatric Disorders
Stevens HE, Smith KM, Rash BG, Vaccarino FM. Neural Stem Cell Regulation, Fibroblast Growth Factors, and the Developmental Origins of Neuropsychiatric Disorders. Frontiers In Neuroscience 2010, 4: 59. PMID: 20877431, PMCID: PMC2944667, DOI: 10.3389/fnins.2010.00059.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsNeural stem cellsFibroblast growth factorGrowth factorPsychiatric disordersNeuropsychiatric disordersBrain-derived growth factorEmbryonic neural stem cellsNeural stem cell regulationStem cell regulationMajor depressionPsychiatric illnessAdult brainNeurodevelopmental underpinningsMental disordersNeuronal precursorsReceptor tyrosine kinasesCandidate susceptibility genesSchizophrenia 1DisordersHomeodomain genesMental retardationAbnormal specificationCell biologyDevelopmental originsMultipotent cells
2008
Regulation of Cerebral Cortical Size and Neuron Number by Fibroblast Growth Factors: Implications for Autism
Vaccarino FM, Grigorenko EL, Smith KM, Stevens HE. Regulation of Cerebral Cortical Size and Neuron Number by Fibroblast Growth Factors: Implications for Autism. Journal Of Autism And Developmental Disorders 2008, 39: 511-520. PMID: 18850329, PMCID: PMC2847619, DOI: 10.1007/s10803-008-0653-8.Peer-Reviewed Original ResearchConceptsFibroblast growth factorCortical sizeNeuron numberExcitatory/inhibitory balanceGrowth factorCortical excitatory neuronsCortical neuron numberCerebral cortical sizeAutism spectrum disorderNetwork excitabilityInhibitory balanceRisk factorsCortical volumePathogenetic pathwaysExcitatory neuronsSpectrum disorderAnimal modelsBrain volumeDevelopmental alterationsPathologyDisordersSocial deficitsBrain sizeFGF genesSeizures
2000
Stem Cells and Neuronal Progenitors and Their Diversity in the CNS: Are Time and Place Important?
Vaccarino F. Stem Cells and Neuronal Progenitors and Their Diversity in the CNS: Are Time and Place Important? The Neuroscientist 2000, 6: 338-352. DOI: 10.1177/107385840000600508.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsDifferent cell typesFibroblast growth factorStem cellsTranscription factorsEarly transcriptional regulatorCell typesHelix transcription factorHomeodomain transcription factorPattern of expressionMultilineage progenitor cellsTranscriptional regulatorsFounder cellsCellular repertoireExtracellular signalsProper assemblyNeuronal progenitorsPositional specificationBasic fibroblast growth factorBody axesImmediate progenyProgenitor cellsGrowth factorRegulatorCellsCNS domains
1999
Erratum: Changes in cerebral cortex size are governed by fibroblast growth factor during embryogenesis
Vaccarino F, Schwartz M, Raballo R, Nilsen J, Rhee J, Zhou M, Doetschman T, Coffin J, Wyland J, Hung Y. Erratum: Changes in cerebral cortex size are governed by fibroblast growth factor during embryogenesis. Nature Neuroscience 1999, 2: 485-485. DOI: 10.1038/8163.Peer-Reviewed Original ResearchChanges in cerebral cortex size are governed by fibroblast growth factor during embryogenesis
Vaccarino F, Schwartz M, Raballo R, Nilsen J, Rhee J, Zhou M, Doetschman T, Coffin J, Wyland J, Hung Y. Changes in cerebral cortex size are governed by fibroblast growth factor during embryogenesis. Nature Neuroscience 1999, 2: 246-253. PMID: 10195217, DOI: 10.1038/6350.Peer-Reviewed Original ResearchConceptsPseudostratified ventricular epitheliumFibroblast growth factor-2Number of gliaAdult cerebral cortexEnd of neurogenesisCerebral cortex sizeFibroblast growth factorGrowth factor 2Cerebral cortexCerebral ventricleSingle microinjectionCortical neuronsBrdU studiesCortical progenitorsVentricular epitheliumCortex sizeGrowth factorRat embryosFGF2 geneEarly neurogenesisFGF receptorsFactor 2GliaNeurogenesisCell cycle length
1995
Basic Fibroblast Growth Factor Increases the Number of Excitatory Neurons Containing Glutamate in the Cerebral Cortex
Vaccarino F, Schwartz M, Hartigan D, Leckman J. Basic Fibroblast Growth Factor Increases the Number of Excitatory Neurons Containing Glutamate in the Cerebral Cortex. Cerebral Cortex 1995, 5: 64-78. PMID: 7719131, DOI: 10.1093/cercor/5.1.64.Peer-Reviewed Original ResearchConceptsBasic fibroblast growth factorNerve growth factorGlutamate-containing neuronsCerebral cortexFibroblast growth factorGrowth factorAspartate-containing neuronsDifferent neurotransmitter phenotypesNumber of GABARatio of glutamateStem cellsNeurotransmitter phenotypeExcitatory neuronsInhibitory neuronsRat telencephalonVentricular zoneBFGF mRNAGABANeuronsCortexGlutamateDiffusible factorsThreefold increaseCellsFactors