2022
Mispatterning and interneuron deficit in Tourette Syndrome basal ganglia organoids
Brady M, Mariani J, Koca Y, Szekely A, King R, Bloch M, Landeros-Weisenberger A, Leckman J, Vaccarino F. Mispatterning and interneuron deficit in Tourette Syndrome basal ganglia organoids. Molecular Psychiatry 2022, 27: 5007-5019. PMID: 36447010, PMCID: PMC9949887, DOI: 10.1038/s41380-022-01880-5.Peer-Reviewed Original ResearchConceptsTourette syndromeInterneuron deficitsGABAergic interneuronsHealthy controlsNeurodevelopmental underpinningsNeuropathological deficitsBG circuitryNeuropsychiatric disordersDecreased differentiationT patientsInterneuronsAltered expressionPotential mechanismsCilia disruptionSonic hedgehogOrganoidsStem cellsTS individualsPluripotent stem cellsGli transcription factorsDeficitsOrganoid differentiationEarly stagesCholinergicPatients
2016
Altering the course of schizophrenia: progress and perspectives
Millan MJ, Andrieux A, Bartzokis G, Cadenhead K, Dazzan P, Fusar-Poli P, Gallinat J, Giedd J, Grayson DR, Heinrichs M, Kahn R, Krebs MO, Leboyer M, Lewis D, Marin O, Marin P, Meyer-Lindenberg A, McGorry P, McGuire P, Owen MJ, Patterson P, Sawa A, Spedding M, Uhlhaas P, Vaccarino F, Wahlestedt C, Weinberger D. Altering the course of schizophrenia: progress and perspectives. Nature Reviews Drug Discovery 2016, 15: 485-515. PMID: 26939910, DOI: 10.1038/nrd.2016.28.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsCourse of schizophreniaCognitive-behavioral interventionsSocial deficitsSchizophrenia-like phenotypeCognitive deficitsCausal pathophysiologyYoung adulthoodYoung adultsPrediction of transitionBrain imagingKey PointsSchizophreniaLevel of individualsHigh-risk individualsSchizophreniaVulnerable young adultsDeficitsPsychosisIndividualsAdult rodentsRisk individualsPharmacological treatmentDisordersAdolescenceUse of biomarkersDistress