Regulation of Cerebral Cortical Size and Neuron Number by Fibroblast Growth Factors: Implications for Autism
Vaccarino FM, Grigorenko EL, Smith KM, Stevens HE. Regulation of Cerebral Cortical Size and Neuron Number by Fibroblast Growth Factors: Implications for Autism. Journal Of Autism And Developmental Disorders 2008, 39: 511-520. PMID: 18850329, PMCID: PMC2847619, DOI: 10.1007/s10803-008-0653-8.Peer-Reviewed Original ResearchConceptsFibroblast growth factorCortical sizeNeuron numberExcitatory/inhibitory balanceGrowth factorCortical excitatory neuronsCortical neuron numberCerebral cortical sizeAutism spectrum disorderNetwork excitabilityInhibitory balanceRisk factorsCortical volumePathogenetic pathwaysExcitatory neuronsSpectrum disorderAnimal modelsBrain volumeDevelopmental alterationsPathologyDisordersSocial deficitsBrain sizeFGF genesSeizures