Hemodialysis and biotransformation of erythrocyte epoxy fatty acids in peripheral tissue
Liu T, Dogan I, Rothe M, Kunz J, Knauf F, Gollasch M, Luft F, Gollasch B. Hemodialysis and biotransformation of erythrocyte epoxy fatty acids in peripheral tissue. Prostaglandins Leukotrienes And Essential Fatty Acids 2022, 181: 102453. PMID: 35633593, DOI: 10.1016/j.plefa.2022.102453.Peer-Reviewed Original ResearchConceptsRed blood cellsHD treatmentHemodialysis treatmentEnd-stage renal disease patientsHydroxyeicosatetraenoic acidHydroxyeicosapentaenoic acidSingle hemodialysis treatmentChronic kidney diseaseRenal disease patientsRenal replacement therapyFatty acid statusVenous blood samplesHydroxydocosahexaenoic acidEpoxy fatty acidsCause of mortalityLOX pathwayRenal failureFatty acidsKidney diseaseDisease patientsVenous bloodCardiovascular functionAcid statusArteriovenous differenceCardiovascular diseaseBioaccumulation of Blood Long-Chain Fatty Acids during Hemodialysis
Liu T, Dogan I, Rothe M, Reichardt J, Knauf F, Gollasch M, Luft F, Gollasch B. Bioaccumulation of Blood Long-Chain Fatty Acids during Hemodialysis. Metabolites 2022, 12: 269. PMID: 35323712, PMCID: PMC8949028, DOI: 10.3390/metabo12030269.Peer-Reviewed Original ResearchChronic kidney diseaseRed blood cellsLong-chain fatty acidsHD treatmentUpper limbEnd-stage renal disease patientsPeripheral tissue perfusionSingle HD treatmentRenal disease patientsFatty acid statusVenous blood samplesFatty acidsCardiovascular eventsESRD patientsHD patientsKidney diseaseDisease patientsVenous bloodHemodialysis treatmentAcid statusUremia altersBlood samplesTissue perfusionLCFA levelsFatty acids nHemodialysis and Plasma Oxylipin Biotransformation in Peripheral Tissue
Liu T, Dogan I, Rothe M, Kunz J, Knauf F, Gollasch M, Luft F, Gollasch B. Hemodialysis and Plasma Oxylipin Biotransformation in Peripheral Tissue. Metabolites 2022, 12: 34. PMID: 35050156, PMCID: PMC8781597, DOI: 10.3390/metabo12010034.Peer-Reviewed Original ResearchArteriovenous differenceEnd-stage renal disease patientsCytochrome P450Renal disease patientsVenous blood samplesArterial blood plasmaImpact of HDSoluble epoxide hydrolase activityVenous blood streamCardiovascular morbidityHemodialysis patientsDisease patientsVenous bloodHD treatmentUpper extremityPeripheral tissuesBlood samplesLipid mediatorsUpper limbEpoxide hydrolase activityBlood streamPatientsMetabolite levelsDeleterious effectsBlood plasma