Characterizing the distinct imaging phenotypes, clinical behavior, and genetic vulnerability of brain maturational subtypes in mood disorders.
Zheng J, Zong X, Tang L, Guo H, Zhao P, Womer F, Zhang X, Tang Y, Wang F. Characterizing the distinct imaging phenotypes, clinical behavior, and genetic vulnerability of brain maturational subtypes in mood disorders. Psychological Medicine 2024, 1-11. PMID: 38804091, DOI: 10.1017/s0033291724000886.Peer-Reviewed Original ResearchGray matter volumeMood disordersGenetic vulnerabilityDepressive disorderHeterogeneity of mood disordersRegional gray matter volumeDrug-free patientsClinical behaviorIncreased genetic vulnerabilityGenetic riskSevere depressive symptomsClinical manifestationsBipolar disorderDrug-naiveFrontal cortexPolygenic risk scoresMatter volumeDepressive symptomsNeurocognitive assessmentCognitive impairmentPrimary motor cortexBehavioral termsDisordersHealthy controlsMotor cortexRepetitive Transcranial Magnetic Stimulation Reversing Abnormal Brain Function in Mood Disorders with Early Life Stress: from preclinical models to clinical applications
Zhao T, Guo H, Yang J, Cai A, Liu J, Zheng J, Xiao Y, Zhao P, Li Y, Luo X, Zhang X, Zhu R, Wang J, Wang F. Repetitive Transcranial Magnetic Stimulation Reversing Abnormal Brain Function in Mood Disorders with Early Life Stress: from preclinical models to clinical applications. Asian Journal Of Psychiatry 2024, 97: 104092. PMID: 38823081, DOI: 10.1016/j.ajp.2024.104092.Peer-Reviewed Original ResearchEarly life stressFunctional magnetic resonance imagingRepetitive transcranial magnetic stimulationMood disorder patientsChronic unpredictable mild stressMood disordersDisorder patientsAbnormal functional activityLife stressCross-species translational studiesImpact of early life stressFunctional magnetic resonance imaging analysisPrimary cortexRisk of mood disordersUnpredictable mild stressTargeting rTMSRTMS interventionAbnormal brain functionIncreased activityDecreased activityDepression-relatedAdolescent ratsCUMS ratsFrontal cortexMild stress