Characterizing the distinct imaging phenotypes, clinical behavior, and genetic vulnerability of brain maturational subtypes in mood disorders.
Zheng J, Zong X, Tang L, Guo H, Zhao P, Womer F, Zhang X, Tang Y, Wang F. Characterizing the distinct imaging phenotypes, clinical behavior, and genetic vulnerability of brain maturational subtypes in mood disorders. Psychological Medicine 2024, 1-11. PMID: 38804091, DOI: 10.1017/s0033291724000886.Peer-Reviewed Original ResearchGray matter volumeMood disordersGenetic vulnerabilityDepressive disorderHeterogeneity of mood disordersRegional gray matter volumeDrug-free patientsClinical behaviorIncreased genetic vulnerabilityGenetic riskSevere depressive symptomsClinical manifestationsBipolar disorderDrug-naiveFrontal cortexPolygenic risk scoresMatter volumeDepressive symptomsNeurocognitive assessmentCognitive impairmentPrimary motor cortexBehavioral termsDisordersHealthy controlsMotor cortex