Integrative omics analysis reveals epigenomic and transcriptomic signatures underlying brain structural deficits in major depressive disorder
Zheng J, Womer F, Tang L, Guo H, Zhang X, Tang Y, Wang F. Integrative omics analysis reveals epigenomic and transcriptomic signatures underlying brain structural deficits in major depressive disorder. Translational Psychiatry 2024, 14: 17. PMID: 38195555, PMCID: PMC10776753, DOI: 10.1038/s41398-023-02724-8.Peer-Reviewed Original ResearchConceptsGray matter volumeBrain structural deficitsFrontal cortexGMV changesStructural deficitsDecreased GMVGray matter volume abnormalitiesInferior frontal cortexAnterior cingulate cortexAllen Human Brain AtlasDifferentially methylated CpG positionsGray matter abnormalitiesHuman Brain AtlasRegionally specific correlationsDepressive disorderCingulate cortexMatter volumeMorphological deficitsMDDBetween-group differencesCortex regionsCortexSynaptic transmission processesDeficitsHealthy controls