2024
Integrative omics analysis reveals epigenomic and transcriptomic signatures underlying brain structural deficits in major depressive disorder
Zheng J, Womer F, Tang L, Guo H, Zhang X, Tang Y, Wang F. Integrative omics analysis reveals epigenomic and transcriptomic signatures underlying brain structural deficits in major depressive disorder. Translational Psychiatry 2024, 14: 17. PMID: 38195555, PMCID: PMC10776753, DOI: 10.1038/s41398-023-02724-8.Peer-Reviewed Original ResearchConceptsGray matter volumeBrain structural deficitsFrontal cortexGMV changesStructural deficitsDecreased GMVGray matter volume abnormalitiesInferior frontal cortexAnterior cingulate cortexAllen Human Brain AtlasDifferentially methylated CpG positionsGray matter abnormalitiesHuman Brain AtlasRegionally specific correlationsDepressive disorderCingulate cortexMatter volumeMorphological deficitsMDDBetween-group differencesCortex regionsCortexSynaptic transmission processesDeficitsHealthy controls
2009
Functional and Structural Connectivity Between the Perigenual Anterior Cingulate and Amygdala in Bipolar Disorder
Wang F, Kalmar JH, He Y, Jackowski M, Chepenik LG, Edmiston E, Tie K, Gong G, Shah MP, Jones M, Uderman J, Constable RT, Blumberg HP. Functional and Structural Connectivity Between the Perigenual Anterior Cingulate and Amygdala in Bipolar Disorder. Biological Psychiatry 2009, 66: 516-521. PMID: 19427632, PMCID: PMC2830492, DOI: 10.1016/j.biopsych.2009.03.023.Peer-Reviewed Original ResearchConceptsPerigenual anterior cingulate cortexHealthy comparison subjectsBipolar disorderFunctional magnetic resonance imagingDiffusion tensor imagingFunctional connectivityWhite matterFractional anisotropyHC groupPerigenual anterior cingulateAnterior cingulate cortexMagnetic resonance imagingGray matter structuresRegional fractional anisotropyWhite matter connectivityEmotional processingFunctional connectivity measuresSignificant positive associationBD groupComparison subjectsAnterior cingulateCingulate cortexResonance imagingSignificant associationBrain regions
2008
Abnormal anterior cingulum integrity in bipolar disorder determined through diffusion tensor imaging
Wang F, Jackowski M, Kalmar JH, Chepenik LG, Tie K, Qiu M, Gong G, Pittman BP, Jones MM, Shah MP, Spencer L, Papademetris X, Constable RT, Blumberg HP. Abnormal anterior cingulum integrity in bipolar disorder determined through diffusion tensor imaging. The British Journal Of Psychiatry 2008, 193: 126-129. PMID: 18669996, PMCID: PMC2732002, DOI: 10.1192/bjp.bp.107.048793.Peer-Reviewed Original ResearchConceptsBipolar disorderWhite matter connectionsFractional anisotropyAnterior cingulumPosterior cingulumAbnormal white matter integrityWhite matter abnormalitiesBipolar disorder groupAnterior cingulate cortexDiffusion tensorWhite matter integrityHealthy groupCingulate cortexNeural systemsHealthy participantsDisorder groupDisordersAbnormalitiesCingulumConvergent evidenceGroupParticipantsEmotional regulation