Aldehyde Dehydrogenase Activation Prevents Reperfusion Arrhythmias by Inhibiting Local Renin Release From Cardiac Mast Cells
Koda K, Salazar-Rodriguez M, Corti F, Chan NY, Estephan R, Silver RB, Mochly-Rosen D, Levi R. Aldehyde Dehydrogenase Activation Prevents Reperfusion Arrhythmias by Inhibiting Local Renin Release From Cardiac Mast Cells. Circulation 2010, 122: 771-781. PMID: 20697027, PMCID: PMC2927811, DOI: 10.1161/circulationaha.110.952481.Peer-Reviewed Original ResearchMeSH KeywordsAldehyde DehydrogenaseAnimalsArrhythmias, CardiacCell DegranulationCell Line, TumorEnzyme ActivationGuinea PigsHumansIschemic Preconditioning, MyocardialMaleMast CellsMyocardial Reperfusion InjuryMyocytes, CardiacProtein Kinase C-epsilonReceptor, Adenosine A2BReceptor, Adenosine A3ReninRenin-Angiotensin SystemConceptsCardiac mast cellsAnti-RA effectRenin-angiotensin systemAldehyde dehydrogenase type 2Ischemic preconditioningIschemia/reperfusionMast cellsRenin releaseALDH2 activationReperfusion arrhythmiasNorepinephrine releaseRAS activationHMC-1Local renin-angiotensin systemBlockade of adenosineLocal RAS activationClassic ischemic preconditioningDehydrogenase type 2New therapeutic targetsCultured mast cellsPKCepsilon inhibitionFibrillation durationMyocardial ischemiaVentricular tachycardiaHearts ex vivo