Mitochondrial aldehyde dehydrogenase-2 activation prevents β-amyloid-induced endothelial cell dysfunction and restores angiogenesis
Solito R, Corti F, Chen C, Mochly-Rosen D, Giachetti A, Ziche M, Donnini S. Mitochondrial aldehyde dehydrogenase-2 activation prevents β-amyloid-induced endothelial cell dysfunction and restores angiogenesis. Journal Of Cell Science 2013, 126: 1952-1961. PMID: 23447675, PMCID: PMC3666252, DOI: 10.1242/jcs.117184.Peer-Reviewed Original ResearchMeSH KeywordsAldehyde DehydrogenaseAldehyde Dehydrogenase, MitochondrialAmyloid beta-PeptidesBenzamidesBenzodioxolesBeta CateninEnzyme ActivationEnzyme ActivatorsHuman Umbilical Vein Endothelial CellsHumansMembrane PotentialsMitochondrial ProteinsNeovascularization, PhysiologicOxidative StressPeptide FragmentsPhosphorylationReactive Oxygen Species