The Syndecan-4/Protein Kinase Cα Pathway Mediates Prostaglandin E2-induced Extracellular Regulated Kinase (ERK) Activation in Endothelial Cells and Angiogenesis in Vivo *
Corti F, Finetti F, Ziche M, Simons M. The Syndecan-4/Protein Kinase Cα Pathway Mediates Prostaglandin E2-induced Extracellular Regulated Kinase (ERK) Activation in Endothelial Cells and Angiogenesis in Vivo *. Journal Of Biological Chemistry 2013, 288: 12712-12721. PMID: 23525101, PMCID: PMC3642317, DOI: 10.1074/jbc.m113.452383.Peer-Reviewed Original ResearchConceptsERK activationExtracellular-regulated kinase activationProteoglycan syndecan-4Protein kinase CαEndothelial cell migrationKinase activationEndothelial cellsSyndecan-4Full rescueCord formationCell migrationActivation of angiogenesisMatrigel assaysTransductionAngiogenic responseAngiogenesisActivationTumor growthImportant roleCellsMutantsMain mediatorVivoSDC4PKCα