Featured Publications
Syndecan 4 is required for endothelial alignment in flow and atheroprotective signaling
Baeyens N, Mulligan-Kehoe MJ, Corti F, Simon DD, Ross TD, Rhodes JM, Wang TZ, Mejean CO, Simons M, Humphrey J, Schwartz MA. Syndecan 4 is required for endothelial alignment in flow and atheroprotective signaling. Proceedings Of The National Academy Of Sciences Of The United States Of America 2014, 111: 17308-17313. PMID: 25404299, PMCID: PMC4260558, DOI: 10.1073/pnas.1413725111.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAtherosclerosisBlotting, WesternCells, CulturedEndothelial CellsFemaleHuman Umbilical Vein Endothelial CellsHumansKruppel-Like Factor 4Kruppel-Like Transcription FactorsMaleMice, Inbred C57BLMice, KnockoutMicroscopy, ConfocalNF-kappa BReverse Transcriptase Polymerase Chain ReactionRNA InterferenceSignal TransductionStress, MechanicalSyndecan-4Vascular Endothelial Growth Factor Receptor-2ConceptsHuman umbilical vein endothelial cellsNF-κBProinflammatory NF-κBAtherosclerotic plaque burdenKruppel-like factor 2Umbilical vein endothelial cellsVEGF receptor 2Appearance of plaquesVein endothelial cellsHypercholesterolemic micePlaque burdenAntiinflammatory pathwayThoracic aortaReceptor 2Endothelial cellsEndothelial alignmentFlow correlatesCausal roleAtherosclerosisFactor 2MiceCyclic stretchLocalization correlatesActivationSyndecan-4
2011
The Expression Level of Ecto-NTP Diphosphohydrolase1/CD39 Modulates Exocytotic and Ischemic Release of Neurotransmitters in a Cellular Model of Sympathetic Neurons
Corti F, Olson K, Marcus A, Levi R. The Expression Level of Ecto-NTP Diphosphohydrolase1/CD39 Modulates Exocytotic and Ischemic Release of Neurotransmitters in a Cellular Model of Sympathetic Neurons. Journal Of Pharmacology And Experimental Therapeutics 2011, 337: 524-532. PMID: 21325440, PMCID: PMC3083107, DOI: 10.1124/jpet.111.179994.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphateAnimalsAntigens, CDApyraseBlotting, WesternDNA PrimersDopamineExocytosisGene Expression Regulation, EnzymologicGene SilencingIschemiaNerve Growth FactorsNeuronsNeurotransmitter AgentsNorepinephrinePC12 CellsPotassiumRatsReceptors, Purinergic P2XReverse Transcriptase Polymerase Chain ReactionRNA, Small InterferingSympathetic Nervous SystemConceptsE-NTPDase1/CD39CD39 expressionTransmitter ATPSympathetic neuronsDopamine releaseExcessive catecholamine releaseNerve growth factor-differentiated PC12 cellsSympathetic nerve terminalsPC12 cellsExocytosis of ATPCellular modelRelease of ATPCD39 overexpressionIschemic releasePrejunctional siteSympathetic nervesCardiac dysfunctionMyocardial ischemiaCatecholamine releaseCD39 deletionNerve terminalsDepolarization-induced exocytosisAutocrine mannerDiphosphohydrolase-1Predominant catecholamine