2014
E‐NTPDase1/CD39 modulates renin release from heart mast cells during ischemia/reperfusion: a novel cardioprotective role
Aldi S, Marino A, Tomita K, Corti F, Anand R, Olson KE, Marcus AJ, Levi R. E‐NTPDase1/CD39 modulates renin release from heart mast cells during ischemia/reperfusion: a novel cardioprotective role. The FASEB Journal 2014, 29: 61-69. PMID: 25318477, PMCID: PMC4285537, DOI: 10.1096/fj.14-261867.Peer-Reviewed Original ResearchConceptsRenin releaseRenin-angiotensin systemMast cellsVentricular fibrillationRAS activationHMC-1Murine bone marrow-derived mast cellsLocal renin-angiotensin systemBone marrow-derived mast cellsCardiac mast cellsNovel cardioprotective roleMarrow-derived mast cellsPurinergic P2X7 receptorIschemia/reperfusionHeart mast cellsCD39 inhibitionCD39 overexpressionP2X7R blockadeNorepinephrine overflowCardioprotective effectsCardioprotective roleP2X7 receptorCD39Pharmacological inhibitionATP release
2010
Aldehyde Dehydrogenase Activation Prevents Reperfusion Arrhythmias by Inhibiting Local Renin Release From Cardiac Mast Cells
Koda K, Salazar-Rodriguez M, Corti F, Chan NY, Estephan R, Silver RB, Mochly-Rosen D, Levi R. Aldehyde Dehydrogenase Activation Prevents Reperfusion Arrhythmias by Inhibiting Local Renin Release From Cardiac Mast Cells. Circulation 2010, 122: 771-781. PMID: 20697027, PMCID: PMC2927811, DOI: 10.1161/circulationaha.110.952481.Peer-Reviewed Original ResearchMeSH KeywordsAldehyde DehydrogenaseAnimalsArrhythmias, CardiacCell DegranulationCell Line, TumorEnzyme ActivationGuinea PigsHumansIschemic Preconditioning, MyocardialMaleMast CellsMyocardial Reperfusion InjuryMyocytes, CardiacProtein Kinase C-epsilonReceptor, Adenosine A2BReceptor, Adenosine A3ReninRenin-Angiotensin SystemConceptsCardiac mast cellsAnti-RA effectRenin-angiotensin systemAldehyde dehydrogenase type 2Ischemic preconditioningIschemia/reperfusionMast cellsRenin releaseALDH2 activationReperfusion arrhythmiasNorepinephrine releaseRAS activationHMC-1Local renin-angiotensin systemBlockade of adenosineLocal RAS activationClassic ischemic preconditioningDehydrogenase type 2New therapeutic targetsCultured mast cellsPKCepsilon inhibitionFibrillation durationMyocardial ischemiaVentricular tachycardiaHearts ex vivoInteraction between Sensory C-fibers and Cardiac Mast Cells in Ischemia/Reperfusion: Activation of a Local Renin-Angiotensin System Culminating in Severe Arrhythmic Dysfunction
Morrey C, Brazin J, Seyedi N, Corti F, Silver RB, Levi R. Interaction between Sensory C-fibers and Cardiac Mast Cells in Ischemia/Reperfusion: Activation of a Local Renin-Angiotensin System Culminating in Severe Arrhythmic Dysfunction. Journal Of Pharmacology And Experimental Therapeutics 2010, 335: 76-84. PMID: 20668055, PMCID: PMC2957783, DOI: 10.1124/jpet.110.172262.Peer-Reviewed Original ResearchMeSH KeywordsAldehydesAnimalsArrhythmias, CardiacBeta-N-AcetylhexosaminidasesCalcitonin Gene-Related PeptideCell DegranulationCells, CulturedFluorescent Antibody TechniqueGuinea PigsIn Vitro TechniquesMaleMast CellsMyocardial Reperfusion InjuryMyocardiumNerve EndingsNerve Fibers, UnmyelinatedNorepinephrineReninRenin-Angiotensin SystemSensory Receptor CellsSubstance PSynaptosomesConceptsRenin-angiotensin systemIschemia/reperfusionCardiac mast cellsSubstance P receptor blockadeLocal renin-angiotensin systemSubstance PMast cellsSensory nervesCultured mast cellsRenin releaseReceptor blockadeCardiac dysfunctionLocal cardiac renin-angiotensin systemCardiac renin-angiotensin systemCardiac nerve terminalsCardiac sensory nervesMast cell reninSubstance P releaseSensory C-fibersMast cell stabilizationSubstance P receptorCardiac synaptosomesReperfusion arrhythmiasNorepinephrine overflowAngiotensin production