2014
E‐NTPDase1/CD39 modulates renin release from heart mast cells during ischemia/reperfusion: a novel cardioprotective role
Aldi S, Marino A, Tomita K, Corti F, Anand R, Olson KE, Marcus AJ, Levi R. E‐NTPDase1/CD39 modulates renin release from heart mast cells during ischemia/reperfusion: a novel cardioprotective role. The FASEB Journal 2014, 29: 61-69. PMID: 25318477, PMCID: PMC4285537, DOI: 10.1096/fj.14-261867.Peer-Reviewed Original ResearchConceptsRenin releaseRenin-angiotensin systemMast cellsVentricular fibrillationRAS activationHMC-1Murine bone marrow-derived mast cellsLocal renin-angiotensin systemBone marrow-derived mast cellsCardiac mast cellsNovel cardioprotective roleMarrow-derived mast cellsPurinergic P2X7 receptorIschemia/reperfusionHeart mast cellsCD39 inhibitionCD39 overexpressionP2X7R blockadeNorepinephrine overflowCardioprotective effectsCardioprotective roleP2X7 receptorCD39Pharmacological inhibitionATP release
2010
Interaction between Sensory C-fibers and Cardiac Mast Cells in Ischemia/Reperfusion: Activation of a Local Renin-Angiotensin System Culminating in Severe Arrhythmic Dysfunction
Morrey C, Brazin J, Seyedi N, Corti F, Silver RB, Levi R. Interaction between Sensory C-fibers and Cardiac Mast Cells in Ischemia/Reperfusion: Activation of a Local Renin-Angiotensin System Culminating in Severe Arrhythmic Dysfunction. Journal Of Pharmacology And Experimental Therapeutics 2010, 335: 76-84. PMID: 20668055, PMCID: PMC2957783, DOI: 10.1124/jpet.110.172262.Peer-Reviewed Original ResearchMeSH KeywordsAldehydesAnimalsArrhythmias, CardiacBeta-N-AcetylhexosaminidasesCalcitonin Gene-Related PeptideCell DegranulationCells, CulturedFluorescent Antibody TechniqueGuinea PigsIn Vitro TechniquesMaleMast CellsMyocardial Reperfusion InjuryMyocardiumNerve EndingsNerve Fibers, UnmyelinatedNorepinephrineReninRenin-Angiotensin SystemSensory Receptor CellsSubstance PSynaptosomesConceptsRenin-angiotensin systemIschemia/reperfusionCardiac mast cellsSubstance P receptor blockadeLocal renin-angiotensin systemSubstance PMast cellsSensory nervesCultured mast cellsRenin releaseReceptor blockadeCardiac dysfunctionLocal cardiac renin-angiotensin systemCardiac renin-angiotensin systemCardiac nerve terminalsCardiac sensory nervesMast cell reninSubstance P releaseSensory C-fibersMast cell stabilizationSubstance P receptorCardiac synaptosomesReperfusion arrhythmiasNorepinephrine overflowAngiotensin production