Dutch and arctic mutant peptides of β amyloid1–40 differentially affect the FGF-2 pathway in brain endothelium
Solito R, Corti F, Fossati S, Mezhericher E, Donnini S, Ghiso J, Giachetti A, Rostagno A, Ziche M. Dutch and arctic mutant peptides of β amyloid1–40 differentially affect the FGF-2 pathway in brain endothelium. Experimental Cell Research 2008, 315: 385-395. PMID: 19061884, PMCID: PMC2764262, DOI: 10.1016/j.yexcr.2008.11.002.Peer-Reviewed Original ResearchConceptsAnti-angiogenic profileDegree of tropismCerebral amyloid angiopathyFGF-2 expressionFGF-2 receptorFibroblast growth factorEndothelial cell proliferationMicrovessel remodelingAmyloid angiopathyBrain endotheliumΒ-amyloid1Brain vesselsInduction of apoptosisAbeta variantsCerebral ECsFGF-2 pathwaysG variantE22GGrowth factorWT peptideFGFR-1Cell proliferationFGF-2Hereditary phenotypesDifferential effects