2020
Improving detection of higher-risk or locally advanced disease features in stage I and II renal cell carcinoma.
Miller N, Derweesh I, Liu M, Bradshaw A, Dutt R, Keiner C, Meagher M, Ghali F, Patel D, Wan F, Shiehmorteza M. Improving detection of higher-risk or locally advanced disease features in stage I and II renal cell carcinoma. Journal Of Clinical Oncology 2020, 38: 625-625. DOI: 10.1200/jco.2020.38.6_suppl.625.Peer-Reviewed Original ResearchRenal cell carcinomaT3a renal cell carcinomaPerinephric fat invasionSinus fat invasionTumor edgeFat invasionVenous invasionCell carcinomaTumor necrosisPerirenal fasciaSingle-institution retrospective analysisT2 renal cell carcinomaAdvanced disease featuresPreoperative clinical stageAccuracy of CTPreoperative CT imagesPathological upstagingPerinephric strandingT3a diseaseUpstaged patientsUpstaged tumorsClinical suspicionMultivariable analysisOncologic riskAggressive diseaseDoes pathologic upstaging to PT3A portend a worsened prognosis when compared to non-upstaged PT3A renal cell carcinoma: Analysis of the National Cancer Database.
Patel D, Ghali F, Meagher M, Bradshaw A, Patel S, Keiner C, Miller N, Dutt R, Murphy J, Derweesh I. Does pathologic upstaging to PT3A portend a worsened prognosis when compared to non-upstaged PT3A renal cell carcinoma: Analysis of the National Cancer Database. Journal Of Clinical Oncology 2020, 38: 624-624. DOI: 10.1200/jco.2020.38.6_suppl.624.Peer-Reviewed Original ResearchPT3a renal cell carcinomaRenal cell carcinomaNational Cancer DatabasePartial nephrectomyClinical stageOverall survivalPT3a tumorsCell carcinomaPathological upstagingUpstaged tumorsCancer DatabaseT3a renal cell carcinomaMultivariable Cox proportional hazardsKaplan-Meier survival analysisPre-treatment detectionRisk stratification protocolCharlson Comorbidity IndexImproved overall survivalFinal pathological analysisAJCC staging systemKaplan-Meier analysisSmaller tumor sizeLower clinical stagePositive margin statusCox proportional hazardsMulticenter comparison of outcomes for clinical and pathologic T3a renal cell carcinoma.
Bradshaw A, Ghali F, Miller N, Keiner C, Dutt R, Meagher M, Yim K, Patel D, Uzzo R, Lane B, Capitanio U, Derweesh I. Multicenter comparison of outcomes for clinical and pathologic T3a renal cell carcinoma. Journal Of Clinical Oncology 2020, 38: 758-758. DOI: 10.1200/jco.2020.38.6_suppl.758.Peer-Reviewed Original ResearchRecurrence-free survivalCancer-specific survivalKaplan-Meier analysisRenal cell carcinomaPT3a renal cell carcinomaOverall survivalMultivariable analysisSecondary outcomesPrimary outcomeCell carcinomaT3a renal cell carcinomaPathologic tumor sizePoor oncologic outcomesRegression multivariable analysisClear cell histologyLog-rank testPre-operative imagingPositive margin rateHigh recurrence rateAdvanced diseaseCell histologyOncologic outcomesVenous involvementMulticenter analysisOS rates
2019
Risk Factors for Upstaging, Recurrence, and Mortality in Clinical T1-2 Renal Cell Carcinoma Patients Upstaged to pT3a Disease: An International Analysis Utilizing the 8th Edition of the Tumor-Node-Metastasis Staging Criteria
Hamilton Z, Capitanio U, Pruthi D, Ghali F, Larcher A, Patel D, Eldefrawy A, Patel S, Cotta B, Bradshaw A, Meagher M, Miller N, Carenzi C, Wan F, Liss M, McGregor T, Montorsi F, Derweesh I. Risk Factors for Upstaging, Recurrence, and Mortality in Clinical T1-2 Renal Cell Carcinoma Patients Upstaged to pT3a Disease: An International Analysis Utilizing the 8th Edition of the Tumor-Node-Metastasis Staging Criteria. Urology 2019, 138: 60-68. PMID: 31836465, DOI: 10.1016/j.urology.2019.11.036.Peer-Reviewed Original ResearchConceptsRecurrence-free survivalRisk of recurrenceRenal cell carcinomaKaplan-Meier analysisHigher clinical stageClinical stageOverall survivalMultivariable analysisPT3a upstagingRisk factorsTumor-NodeT3a renal cell carcinomaRenal cell carcinoma patientsRisk of upstagingCell carcinoma patientsMulticenter retrospective analysisPerinephric fat invasionInitial clinical stageRenal vein invasionType of surgeryPT3a diseaseCarcinoma patientsPrimary outcomeFat invasionRenal vein