2024
Adjuvant Chemotherapy and Survival After Radical Cystectomy in Histologic Subtype Bladder Cancer
Koehne E, Bakaloudi D, Ghali F, Nyame Y, Schade G, Grivas P, Yezefski T, Hawley J, Yu E, Hsieh A, Montgomery R, Psutka S, Gore J, Wright J. Adjuvant Chemotherapy and Survival After Radical Cystectomy in Histologic Subtype Bladder Cancer. Clinical Genitourinary Cancer 2024, 22: 102100. PMID: 38763862, DOI: 10.1016/j.clgc.2024.102100.Peer-Reviewed Original ResearchNational Cancer DatabaseAdjuvant chemotherapyReceipt of ACRadical cystectomyBladder cancerOverall survivalAssociated with significantly longer OSAssociated with OS benefitNon-metastatic bladder cancerMultivariate Cox regression analysisPrevalence of adenocarcinomaSquamous cell histologyMultivariate Cox regressionCox regression analysisMultivariate logistic regressionAssociated with lower oddsAssociated with greater oddsNeuroendocrine histologyLonger OSOS benefitCell histologyHistological subtypesCancer DatabaseClinicopathological featuresCox regression
2021
Evaluation of Insurance Coverage and Cancer Stage at Diagnosis Among Low-Income Adults With Renal Cell Carcinoma After Passage of the Patient Protection and Affordable Care Act
Javier-DesLoges JF, Yuan J, Soliman S, Hakimi K, Meagher MF, Ghali F, Hsiang W, Patel DN, Kim SP, Murphy JD, Parsons JK, Derweesh IH. Evaluation of Insurance Coverage and Cancer Stage at Diagnosis Among Low-Income Adults With Renal Cell Carcinoma After Passage of the Patient Protection and Affordable Care Act. JAMA Network Open 2021, 4: e2116267. PMID: 34269808, PMCID: PMC8285737, DOI: 10.1001/jamanetworkopen.2021.16267.Peer-Reviewed Original ResearchConceptsLow-income patientsRenal cell carcinomaAffordable Care ActACA implementationNonexpansion statesLocalized diseaseAbsolute percentage changeCell carcinomaCancer stageExpansion statesNational Cancer DatabaseProportion of patientsRetrospective cohort analysisInsurance coveragePatient ProtectionCare ActMedicaid expansion statesInsurance coverage statusLow-income adultsEarly RCC detectionExpansion of insuranceSecondary outcomesInsurance statusAdjusted differenceCancer DatabaseThe association between the Affordable Care Act on insurance status, cancer stage, and overall survival in patients with renal cell carcinoma.
Javier-Desloges J, Yuan J, Soliman S, Hakimi K, Meagher M, Ghali F, Hsiang W, Patel D, Murphy J, Kim S, Derweesh I. The association between the Affordable Care Act on insurance status, cancer stage, and overall survival in patients with renal cell carcinoma. Journal Of Clinical Oncology 2021, 39: 281-281. DOI: 10.1200/jco.2021.39.6_suppl.281.Peer-Reviewed Original ResearchRenal cell carcinomaMiddle-income patientsNon-expansion statesAffordable Care ActAbsolute percentage changeIncome patientsInsurance statusExpansion statesCox regression multivariable analysisNational Cancer DatabaseRegression multivariable analysisHigh-income patientsLow-income patientsInsurance coverage statusImplementation of ACALow incomeCause mortalityPatients 40Overall survivalStage diseaseAdvanced cancerMultivariable analysisCancer groupStage migrationCell carcinoma
2020
Utilization of renal mass biopsy in patients with localized renal cell carcinoma: A population-based study utilizing the National Cancer Database
Patel DN, Ghali F, Meagher MF, Javier-Desloges J, Patel SH, Soliman S, Hakimi K, Yuan J, Murphy J, Derweesh IH. Utilization of renal mass biopsy in patients with localized renal cell carcinoma: A population-based study utilizing the National Cancer Database. Urologic Oncology Seminars And Original Investigations 2020, 39: 79.e1-79.e8. PMID: 33160847, DOI: 10.1016/j.urolonc.2020.10.015.Peer-Reviewed Original ResearchConceptsUse of RMBRenal mass biopsyRenal cell carcinomaNational Cancer DatabaseCell carcinomaMultivariable analysisCancer DatabaseMass biopsyCharlson Comorbidity IndexCurrent guideline recommendationsYear of diagnosisPopulation-based studySmall renal massesComorbidity indexSurgical treatmentGuideline recommendationsTumor sizeRenal massesPersistent underutilizationPatientsCarcinomaStudy periodTumorsBiopsyHigh rateImpact of positive surgical margins on survival after partial nephrectomy in localized kidney cancer: analysis of the National Cancer Database
Ryan S, Patel D, Ghali F, Patel S, Sarkar R, Yim K, Eldefrawy A, Cotta B, Bradshaw A, Meagher M, Hamilton Z, Murphy J, Derweesh I. Impact of positive surgical margins on survival after partial nephrectomy in localized kidney cancer: analysis of the National Cancer Database. Minerva Urologica E Nefrologica 2020, 73: 233-244. PMID: 32748614, DOI: 10.23736/s2724-6051.20.03728-5.Peer-Reviewed Original ResearchConceptsPositive surgical marginsKaplan-Meier analysisRenal cell carcinomaNational Cancer DatabaseOverall survivalPartial nephrectomyMultivariable analysisSurgical marginsPathological stageCancer DatabaseCox regression multivariable analysisN0M0 renal cell carcinomaUS National Cancer DatabaseImpact of PSMRegression multivariable analysisPT3a diseaseCause mortalityMargin statusNegative marginsResection strategyCell carcinomaAggressive surveillanceRetrospective analysisKidney cancerPatientsPT178 Utility and outcomes of lymph node dissection in T2-3 renal cell carcinoma: Analysis of the national cancer database
Ghali F, Patel D, Meagher M, Patel S, Bradshaw A, Dutt R, Miller N, Keiner C, Eldefrawy A, Murphy J, Derweesh I. PT178 Utility and outcomes of lymph node dissection in T2-3 renal cell carcinoma: Analysis of the national cancer database. European Urology Open Science 2020, 19: e1955-e1956. DOI: 10.1016/s2666-1683(20)33916-1.Peer-Reviewed Original ResearchLymph node dissectionNational Cancer DatabaseRenal cell carcinomaNode dissectionCell carcinomaCancer DatabaseCarcinomaThe impact of metastasis location on overall survival among patients with renal cell carcinoma.
Patel D, Ghali F, Meagher M, Meagher M, Bradshaw A, Patel S, Keiner C, Miller N, Dutt R, Murphy J, Derweesh I. The impact of metastasis location on overall survival among patients with renal cell carcinoma. Journal Of Clinical Oncology 2020, 38: 621-621. DOI: 10.1200/jco.2020.38.6_suppl.621.Peer-Reviewed Original ResearchMetastatic renal cell carcinomaRenal cell carcinomaNational Cancer DatabaseLiver/lung metastasisOverall survivalBone metastasesLung metastasesCell carcinomaInstitutional databaseUnivariate analysisMetastasis locationWorse OSSite metastasisDisease locationMultivariable Cox proportional hazardsKaplan-Meier survival analysisCurrent staging guidelinesLung/liver metastasisLog-rank testingWorse overall survivalHeterogeneity of patientsCox proportional hazardsLung/liverLiver metastasesMetastatic diseaseThe role of lymph node dissection in pT2-3 renal cell carcinoma: Analysis of the National Cancer Database.
Ghali F, Patel D, Meagher M, Bradshaw A, Patel S, Dutt R, Murphy J, Derweesh I. The role of lymph node dissection in pT2-3 renal cell carcinoma: Analysis of the National Cancer Database. Journal Of Clinical Oncology 2020, 38: 756-756. DOI: 10.1200/jco.2020.38.6_suppl.756.Peer-Reviewed Original ResearchMultivariable Cox regressionKaplan-Meier analysisImpact of LNDNational Cancer DatabaseClear cell histologyCell histologyRadical nephrectomyCancer DatabaseCaucasian raceHigh gradeLarge population-based datasetNon-specific histologyLymph node dissectionHigh-grade diseaseHigh-risk cohortRenal cell carcinomaPopulation-based datasetCharlson scoreNode dissectionCause mortalityGrade diseasePT2 patientsCox regressionMale sexPT3 patientsUtilization of renal mass biopsy in patients with localized renal cell carcinoma: A population-based study utilizing the National Cancer Database.
Patel D, Ghali F, Patel S, Miller N, Bradshaw A, Meagher M, Rivera-Sanfeliz G, Murphy J, Derweesh I. Utilization of renal mass biopsy in patients with localized renal cell carcinoma: A population-based study utilizing the National Cancer Database. Journal Of Clinical Oncology 2020, 38: 662-662. DOI: 10.1200/jco.2020.38.6_suppl.662.Peer-Reviewed Original ResearchUse of RMBRenal cell carcinomaRenal mass biopsyNational Cancer DatabaseMultivariable logistic regressionTumor sizeCell carcinomaActive surveillanceCancer DatabaseMass biopsyLogistic regressionStudy periodCharlson Comorbidity IndexYear of diagnosisPopulation-based studyType of treatmentComorbidity indexSicker patientsBlack raceTumors 2Recent guidelinesTreatment strategiesPatientsAblation treatmentTumorsDoes delay in time to surgery impact outcome in renal cell carcinoma: Analysis based on tumor size utilizing the National Cancer Database.
Patel D, Ghali F, Meagher M, Bradshaw A, Patel S, Murphy J, Derweesh I. Does delay in time to surgery impact outcome in renal cell carcinoma: Analysis based on tumor size utilizing the National Cancer Database. Journal Of Clinical Oncology 2020, 38: 664-664. DOI: 10.1200/jco.2020.38.6_suppl.664.Peer-Reviewed Original ResearchMultivariable Cox proportional hazardsNational Cancer DatabaseRenal cell carcinomaKaplan-Meier analysisYears of ageTumor sizeSurgery delayWorse OSOverall survivalHealthy patientsCell carcinomaCancer DatabaseLocalized Renal Cell CarcinomaNon-private insuranceTumor size 2Charlson comorbidity scoreCox proportional hazardsComorbidity scoreSurgical treatmentSurvival impactMedian timeEntire cohortFourth quartileBlack raceActive surveillanceDoes pathologic upstaging to PT3A portend a worsened prognosis when compared to non-upstaged PT3A renal cell carcinoma: Analysis of the National Cancer Database.
Patel D, Ghali F, Meagher M, Bradshaw A, Patel S, Keiner C, Miller N, Dutt R, Murphy J, Derweesh I. Does pathologic upstaging to PT3A portend a worsened prognosis when compared to non-upstaged PT3A renal cell carcinoma: Analysis of the National Cancer Database. Journal Of Clinical Oncology 2020, 38: 624-624. DOI: 10.1200/jco.2020.38.6_suppl.624.Peer-Reviewed Original ResearchPT3a renal cell carcinomaRenal cell carcinomaNational Cancer DatabasePartial nephrectomyClinical stageOverall survivalPT3a tumorsCell carcinomaPathological upstagingUpstaged tumorsCancer DatabaseT3a renal cell carcinomaMultivariable Cox proportional hazardsKaplan-Meier survival analysisPre-treatment detectionRisk stratification protocolCharlson Comorbidity IndexImproved overall survivalFinal pathological analysisAJCC staging systemKaplan-Meier analysisSmaller tumor sizeLower clinical stagePositive margin statusCox proportional hazards
2019
Prostatectomy in men with clinically positive lymph nodes.
Ghali F, Ryan S, Hansen M, Hayn M, Sammon J, Sarkar R, Murphy J, Kader A, Rose B. Prostatectomy in men with clinically positive lymph nodes. Journal Of Clinical Oncology 2019, 37: 327-327. DOI: 10.1200/jco.2019.37.7_suppl.327.Peer-Reviewed Original ResearchCox proportional hazards modelPositive lymph nodesBiopsy Gleason scoreProportional hazards modelProstate cancerLymph nodesPCa patientsGleason scoreHazards modelClinical positive lymph nodesHigh-risk prostate cancerNational Cancer DatabaseRisk prostate cancerPrimary treatment modalityPositive surgical marginsPathologic T stageDifficult clinical scenariosMedian followWorse OSNodal statusRisk patientsSystemic therapyClinical stagingSurgical marginsT stage