2022
Impact of Metastasectomy on Cancer Specific and Overall Survival in Metastatic Renal Cell Carcinoma: Analysis of the REMARCC Registry
Meagher MF, Mir MC, Autorino R, Minervini A, Kriegmair M, Maurer T, Porpiglia F, Van Bruwaene S, Linares E, Hevia V, Musquera M, Roussel E, Pavan N, Antonelli A, Zhang S, Ghali F, Patel D, Javier-Desloges J, Bradshaw A, Rubio J, Guruli G, Tracey A, Campi R, Albersen M, Furlan M, McKay RR, Derweesh IH. Impact of Metastasectomy on Cancer Specific and Overall Survival in Metastatic Renal Cell Carcinoma: Analysis of the REMARCC Registry. Clinical Genitourinary Cancer 2022, 20: 326-333. PMID: 35585014, DOI: 10.1016/j.clgc.2022.03.013.Peer-Reviewed Original ResearchConceptsMetastatic renal cell carcinomaCancer-specific mortalityKaplan-Meier analysisHigh-risk groupImpact of metastasectomyRenal cell carcinomaCell carcinomaMultimodal management strategyPotential prognostic variablesHigh-risk patientsMulticenter retrospective analysisCox regression analysisIntermediate-risk subgroupsMedian OSMRCC patientsCause mortalitySurgical metastasectomyOverall survivalPrimary outcomeSecondary outcomesSpecific survivalCox regressionCancer-SpecificTreatment paradigmMetastasectomy
2020
836 Performance of a new risk assessment tool for patients with metastatic renal cell carcinoma undergoing cytoreductive nephrectomy in the targeted therapy era: REMARCC score
Maresma M, Marchioni M, Campi R, Minervini A, Kriegmair M, Heck M, Porpiglia F, Van Bruwaene S, Linares E, Hevia V, Musquera M, Derweesh I, Ghali F, Autorino R, Veccia A, Roussel E, Albertsen M, Pavan N, Antonellia A, Palumbo C, Capitanio U, Klatte T, Erdem S, Rubio-Briones J, Group Y. 836 Performance of a new risk assessment tool for patients with metastatic renal cell carcinoma undergoing cytoreductive nephrectomy in the targeted therapy era: REMARCC score. European Urology Open Science 2020, 19: e1266-e1267. DOI: 10.1016/s2666-1683(20)33434-0.Peer-Reviewed Original Research846 Impact of metastasectomy on cancer specific and overall survival in metastatic renal cell carcinoma: Analysis of the REMARCC registry
Meagher M, Mir M, Rubio J, Campi R, Minervini A, Kriegmair M, Heck M, Van Bruwaene S, Linares E, Hevia V, Musquera M, D’anna M, Ghali F, Patel D, Bradshaw A, Autorino R, Guruli G, Rousel E, Albertsen M, Pavan N, Claps F, Antonelli A, Palumbo C, Marchioni M, Derweesh I. 846 Impact of metastasectomy on cancer specific and overall survival in metastatic renal cell carcinoma: Analysis of the REMARCC registry. European Urology Open Science 2020, 19: e1285-e1286. DOI: 10.1016/s2666-1683(20)33444-3.Peer-Reviewed Original ResearchMetastatic renal cell carcinomaImpact of metastasectomyRenal cell carcinomaOverall survivalCell carcinomaMetastasectomyCarcinomaRegistryCancerRates and Predictors of Perioperative Complications in Cytoreductive Nephrectomy: Analysis of the Registry for Metastatic Renal Cell Carcinoma
Roussel E, Campi R, Larcher A, Verbiest A, Antonelli A, Palumbo C, Derweesh I, Ghali F, Bradshaw A, Meagher M, Heck M, Amiel T, Kriegmair M, Rubio J, Musquera M, D’Anna M, Autorino R, Guruli G, Veccia A, Linares-Espinos E, Van Bruwaene S, Hevia V, Porpiglia F, Checcucci E, Minervini A, Mari A, Pavan N, Claps F, Marchioni M, Capitanio U, Beuselinck B, Mir M, Albersen M, Group O. Rates and Predictors of Perioperative Complications in Cytoreductive Nephrectomy: Analysis of the Registry for Metastatic Renal Cell Carcinoma. European Urology Oncology 2020, 3: 523-529. PMID: 32414697, DOI: 10.1016/j.euo.2020.04.006.Peer-Reviewed Original ResearchConceptsCytoreductive nephrectomyPostoperative complicationsMultivariable analysisMRCC patientsIntraoperative complicationsBlood lossSignificant predictorsComplex surgeryMetastatic renal cell carcinoma patientsHigher intraoperative blood lossHigh-grade postoperative complicationsMetastatic renal cell carcinomaRenal cell carcinoma patientsCase loadHigh-grade morbidityMultiple postoperative complicationsIntraoperative blood lossMetastatic renal cancerCell carcinoma patientsPrimary kidney tumorsRenal cell carcinomaLogistic regression analysisTherapy eraPerioperative complicationsPostoperative morbidityThe impact of metastasis location on overall survival among patients with renal cell carcinoma.
Patel D, Ghali F, Meagher M, Meagher M, Bradshaw A, Patel S, Keiner C, Miller N, Dutt R, Murphy J, Derweesh I. The impact of metastasis location on overall survival among patients with renal cell carcinoma. Journal Of Clinical Oncology 2020, 38: 621-621. DOI: 10.1200/jco.2020.38.6_suppl.621.Peer-Reviewed Original ResearchMetastatic renal cell carcinomaRenal cell carcinomaNational Cancer DatabaseLiver/lung metastasisOverall survivalBone metastasesLung metastasesCell carcinomaInstitutional databaseUnivariate analysisMetastasis locationWorse OSSite metastasisDisease locationMultivariable Cox proportional hazardsKaplan-Meier survival analysisCurrent staging guidelinesLung/liver metastasisLog-rank testingWorse overall survivalHeterogeneity of patientsCox proportional hazardsLung/liverLiver metastasesMetastatic disease
2019
Current Status of Immunotherapy for Localized and Locally Advanced Renal Cell Carcinoma
Ghali F, Patel S, Derweesh I. Current Status of Immunotherapy for Localized and Locally Advanced Renal Cell Carcinoma. Journal Of Oncology 2019, 2019: 7309205. PMID: 31057615, PMCID: PMC6463563, DOI: 10.1155/2019/7309205.Peer-Reviewed Original ResearchAdvanced renal cell carcinomaRenal cell carcinomaAdjuvant therapyNeoadjuvant therapyCell carcinomaMetastatic renal cell carcinomaTyrosine kinase inhibitor sunitinibPresurgical tumor reductionSystemic therapy strategiesFirst-line therapyPhase II studyNephron-sparing surgeryPrimary renal tumorsKinase inhibitor sunitinibNeoadjuvant immunotherapyNeoadjuvant strategiesII studyLine therapySurgical resectionRadical resectionCheckpoint inhibitionAdjuvant agentTumor reductionRenal tumorsClinical trials