2022
Impact of Metastasectomy on Cancer Specific and Overall Survival in Metastatic Renal Cell Carcinoma: Analysis of the REMARCC Registry
Meagher MF, Mir MC, Autorino R, Minervini A, Kriegmair M, Maurer T, Porpiglia F, Van Bruwaene S, Linares E, Hevia V, Musquera M, Roussel E, Pavan N, Antonelli A, Zhang S, Ghali F, Patel D, Javier-Desloges J, Bradshaw A, Rubio J, Guruli G, Tracey A, Campi R, Albersen M, Furlan M, McKay RR, Derweesh IH. Impact of Metastasectomy on Cancer Specific and Overall Survival in Metastatic Renal Cell Carcinoma: Analysis of the REMARCC Registry. Clinical Genitourinary Cancer 2022, 20: 326-333. PMID: 35585014, DOI: 10.1016/j.clgc.2022.03.013.Peer-Reviewed Original ResearchConceptsMetastatic renal cell carcinomaCancer-specific mortalityKaplan-Meier analysisHigh-risk groupImpact of metastasectomyRenal cell carcinomaCell carcinomaMultimodal management strategyPotential prognostic variablesHigh-risk patientsMulticenter retrospective analysisCox regression analysisIntermediate-risk subgroupsMedian OSMRCC patientsCause mortalitySurgical metastasectomyOverall survivalPrimary outcomeSecondary outcomesSpecific survivalCox regressionCancer-SpecificTreatment paradigmMetastasectomyDoes presence of diabetes mellitus impact patient oncological outcomes in renal cell carcinoma: A multicenter analysis.
Saidian A, Walia A, Patil D, Saito K, Patel D, Nguyen M, Chakoumakos M, Ghali F, Narasimhan R, Perry J, Meagher M, Yasuda Y, Fujii Y, Master V. Does presence of diabetes mellitus impact patient oncological outcomes in renal cell carcinoma: A multicenter analysis. Journal Of Clinical Oncology 2022, 40: 325-325. DOI: 10.1200/jco.2022.40.6_suppl.325.Peer-Reviewed Original ResearchRenal cell carcinomaProgression-free survivalKaplan-Meier analysisCancer-specific survivalIndependent risk factorMultivariable analysisDiabetes mellitusRisk factorsOverall survivalCell carcinomaStage ICox regression multivariable analysisImpact of DMPatients' oncological outcomesNon-diabetic patientsRegression multivariable analysisOncologic effectCause mortalityOncological outcomesDiabetic patientsMulticenter analysisMeier analysisMale sexRCC patientsStage subgroupsDisparities in Cancer Specific and Overall Survival Outcomes in African Americans With Renal Cell Carcinoma: Analysis From the International Marker Consortium for Renal Cancer (INMARC)
Meagher M, Patil D, Saito K, Javier-Desloges J, Bradshaw A, Patel S, Cotta B, Yasuda Y, Eldefrawy A, Ghali F, Nasseri R, Wan F, Fujii Y, Master V, Derweesh I. Disparities in Cancer Specific and Overall Survival Outcomes in African Americans With Renal Cell Carcinoma: Analysis From the International Marker Consortium for Renal Cancer (INMARC). Urology 2022, 163: 164-176. PMID: 34995562, DOI: 10.1016/j.urology.2021.12.022.Peer-Reviewed Original ResearchConceptsRenal cell carcinomaCancer-specific mortalityCancer-specific survivalKaplan-Meier analysisCause mortalityOverall survivalMultivariable analysisSurvival outcomesCell carcinomaStage IIIStage IFive-year cancer-specific survivalAfrican AmericansNon-African American patientsRenal cancer databasePapillary renal cell carcinomaOverall survival outcomesAfrican American raceStage III/IV RCCHigher stageIndolent histologiesSecondary outcomesPrimary outcomeRadical nephrectomyPositive margins
2021
Evaluation of the association of health care system access with kidney cancer surgical outcomes for hispanic and non-hispanic white patients
Javier-DesLoges JF, Meagher MF, Walia A, Nguyen MV, Perry JM, Narasimhan RS, Hakimi K, Soliman S, Yuan J, Chakoumakos MA, Ghali F, Patel DN, Wan F, Murphy JD, Derweesh IH. Evaluation of the association of health care system access with kidney cancer surgical outcomes for hispanic and non-hispanic white patients. Urologic Oncology Seminars And Original Investigations 2021, 39: 837.e1-837.e7. PMID: 34580026, DOI: 10.1016/j.urolonc.2021.08.021.Peer-Reviewed Original ResearchConceptsNon-Hispanic white patientsCancer-specific survivalRenal cell carcinomaMedically Underserved AreasCause mortalityWhite patientsHealth care system accessSpecific survivalNon-Hispanic whitesLocalized Renal Cell CarcinomaTertiary referral centerCause mortality riskKaplan-Meier analysisLog-rank testCancer surgical outcomesOverall survivalReferral centerSecondary outcomesPrimary outcomeHispanic patientsMeier analysisCox regressionSurgical outcomesCell carcinomaRisk factorsMP42-17 ASSOCIATION OF TUMOR HISTOLOGY ON IMPACT OF LYMPH NODE DISSECTION ON SURVIVAL IN T2-T3 RENAL CELL CARCINOMA: ANALYSIS OF THE NATIONAL CANCER DATABASE
Ghali F, Cedars B, Patel D, Javier-Desloges J, Meagher M, Yuan J, Hakimi K, Soliman S, Patel S, Ballon-Landa E, Murphy J, Derweesh I. MP42-17 ASSOCIATION OF TUMOR HISTOLOGY ON IMPACT OF LYMPH NODE DISSECTION ON SURVIVAL IN T2-T3 RENAL CELL CARCINOMA: ANALYSIS OF THE NATIONAL CANCER DATABASE. Journal Of Urology 2021, 206: e778-e779. DOI: 10.1097/ju.0000000000002063.17.Peer-Reviewed Original ResearchMP45-12 THE ASSOCIATION BETWEEN THE AFFORDABLE CARE ACT ON INSURANCE STATUS, CANCER STAGE, AND OVERALL SURVIVAL IN PATIENTS WITH RENAL CELL CARCINOMA
Javier-DesLoges J, Hakimi K, Yuan J, Soliman S, Meagher M, Ghali F, Nawalade V, Patel D, Murphy J, Jolla, CA L, Kim S, Derweesh I. MP45-12 THE ASSOCIATION BETWEEN THE AFFORDABLE CARE ACT ON INSURANCE STATUS, CANCER STAGE, AND OVERALL SURVIVAL IN PATIENTS WITH RENAL CELL CARCINOMA. Journal Of Urology 2021, 206: e807-e808. DOI: 10.1097/ju.0000000000002066.12.Peer-Reviewed Original ResearchEvaluation of Insurance Coverage and Cancer Stage at Diagnosis Among Low-Income Adults With Renal Cell Carcinoma After Passage of the Patient Protection and Affordable Care Act
Javier-DesLoges JF, Yuan J, Soliman S, Hakimi K, Meagher MF, Ghali F, Hsiang W, Patel DN, Kim SP, Murphy JD, Parsons JK, Derweesh IH. Evaluation of Insurance Coverage and Cancer Stage at Diagnosis Among Low-Income Adults With Renal Cell Carcinoma After Passage of the Patient Protection and Affordable Care Act. JAMA Network Open 2021, 4: e2116267. PMID: 34269808, PMCID: PMC8285737, DOI: 10.1001/jamanetworkopen.2021.16267.Peer-Reviewed Original ResearchConceptsLow-income patientsRenal cell carcinomaAffordable Care ActACA implementationNonexpansion statesLocalized diseaseAbsolute percentage changeCell carcinomaCancer stageExpansion statesNational Cancer DatabaseProportion of patientsRetrospective cohort analysisInsurance coveragePatient ProtectionCare ActMedicaid expansion statesInsurance coverage statusLow-income adultsEarly RCC detectionExpansion of insuranceSecondary outcomesInsurance statusAdjusted differenceCancer DatabaseThe association between the Affordable Care Act on insurance status, cancer stage, and overall survival in patients with renal cell carcinoma.
Javier-Desloges J, Yuan J, Soliman S, Hakimi K, Meagher M, Ghali F, Hsiang W, Patel D, Murphy J, Kim S, Derweesh I. The association between the Affordable Care Act on insurance status, cancer stage, and overall survival in patients with renal cell carcinoma. Journal Of Clinical Oncology 2021, 39: 281-281. DOI: 10.1200/jco.2021.39.6_suppl.281.Peer-Reviewed Original ResearchRenal cell carcinomaMiddle-income patientsNon-expansion statesAffordable Care ActAbsolute percentage changeIncome patientsInsurance statusExpansion statesCox regression multivariable analysisNational Cancer DatabaseRegression multivariable analysisHigh-income patientsLow-income patientsInsurance coverage statusImplementation of ACALow incomeCause mortalityPatients 40Overall survivalStage diseaseAdvanced cancerMultivariable analysisCancer groupStage migrationCell carcinoma
2020
Utilization of renal mass biopsy in patients with localized renal cell carcinoma: A population-based study utilizing the National Cancer Database
Patel DN, Ghali F, Meagher MF, Javier-Desloges J, Patel SH, Soliman S, Hakimi K, Yuan J, Murphy J, Derweesh IH. Utilization of renal mass biopsy in patients with localized renal cell carcinoma: A population-based study utilizing the National Cancer Database. Urologic Oncology Seminars And Original Investigations 2020, 39: 79.e1-79.e8. PMID: 33160847, DOI: 10.1016/j.urolonc.2020.10.015.Peer-Reviewed Original ResearchConceptsUse of RMBRenal mass biopsyRenal cell carcinomaNational Cancer DatabaseCell carcinomaMultivariable analysisCancer DatabaseMass biopsyCharlson Comorbidity IndexCurrent guideline recommendationsYear of diagnosisPopulation-based studySmall renal massesComorbidity indexSurgical treatmentGuideline recommendationsTumor sizeRenal massesPersistent underutilizationPatientsCarcinomaStudy periodTumorsBiopsyHigh rateImpact of positive surgical margins on survival after partial nephrectomy in localized kidney cancer: analysis of the National Cancer Database
Ryan S, Patel D, Ghali F, Patel S, Sarkar R, Yim K, Eldefrawy A, Cotta B, Bradshaw A, Meagher M, Hamilton Z, Murphy J, Derweesh I. Impact of positive surgical margins on survival after partial nephrectomy in localized kidney cancer: analysis of the National Cancer Database. Minerva Urologica E Nefrologica 2020, 73: 233-244. PMID: 32748614, DOI: 10.23736/s2724-6051.20.03728-5.Peer-Reviewed Original ResearchConceptsPositive surgical marginsKaplan-Meier analysisRenal cell carcinomaNational Cancer DatabaseOverall survivalPartial nephrectomyMultivariable analysisSurgical marginsPathological stageCancer DatabaseCox regression multivariable analysisN0M0 renal cell carcinomaUS National Cancer DatabaseImpact of PSMRegression multivariable analysisPT3a diseaseCause mortalityMargin statusNegative marginsResection strategyCell carcinomaAggressive surveillanceRetrospective analysisKidney cancerPatients101 Impact of diabetes mellitus on functional and survival outcomes in renal cell carcinoma: An international multicenter study
Dutt R, Meagher M, Patil D, Saito K, Patel D, Ghali F, Keiner C, Miller N, Bradshaw A, Wan F, Yasuda Y, Fujii Y, Master V, Derweesh I. 101 Impact of diabetes mellitus on functional and survival outcomes in renal cell carcinoma: An international multicenter study. European Urology Open Science 2020, 19: e236-e237. DOI: 10.1016/s2666-1683(20)32709-9.Peer-Reviewed Original Research836 Performance of a new risk assessment tool for patients with metastatic renal cell carcinoma undergoing cytoreductive nephrectomy in the targeted therapy era: REMARCC score
Maresma M, Marchioni M, Campi R, Minervini A, Kriegmair M, Heck M, Porpiglia F, Van Bruwaene S, Linares E, Hevia V, Musquera M, Derweesh I, Ghali F, Autorino R, Veccia A, Roussel E, Albertsen M, Pavan N, Antonellia A, Palumbo C, Capitanio U, Klatte T, Erdem S, Rubio-Briones J, Group Y. 836 Performance of a new risk assessment tool for patients with metastatic renal cell carcinoma undergoing cytoreductive nephrectomy in the targeted therapy era: REMARCC score. European Urology Open Science 2020, 19: e1266-e1267. DOI: 10.1016/s2666-1683(20)33434-0.Peer-Reviewed Original Research846 Impact of metastasectomy on cancer specific and overall survival in metastatic renal cell carcinoma: Analysis of the REMARCC registry
Meagher M, Mir M, Rubio J, Campi R, Minervini A, Kriegmair M, Heck M, Van Bruwaene S, Linares E, Hevia V, Musquera M, D’anna M, Ghali F, Patel D, Bradshaw A, Autorino R, Guruli G, Rousel E, Albertsen M, Pavan N, Claps F, Antonelli A, Palumbo C, Marchioni M, Derweesh I. 846 Impact of metastasectomy on cancer specific and overall survival in metastatic renal cell carcinoma: Analysis of the REMARCC registry. European Urology Open Science 2020, 19: e1285-e1286. DOI: 10.1016/s2666-1683(20)33444-3.Peer-Reviewed Original ResearchPT178 Utility and outcomes of lymph node dissection in T2-3 renal cell carcinoma: Analysis of the national cancer database
Ghali F, Patel D, Meagher M, Patel S, Bradshaw A, Dutt R, Miller N, Keiner C, Eldefrawy A, Murphy J, Derweesh I. PT178 Utility and outcomes of lymph node dissection in T2-3 renal cell carcinoma: Analysis of the national cancer database. European Urology Open Science 2020, 19: e1955-e1956. DOI: 10.1016/s2666-1683(20)33916-1.Peer-Reviewed Original ResearchOncologic and Functional Outcomes of Radical and Partial Nephrectomy in pT3a Pathologically Upstaged Renal Cell Carcinoma: A Multi-institutional Analysis
Patel S, Uzzo R, Larcher A, Peyronnet B, Lane B, Pruthi D, Reddy M, Capitanio U, Joshi S, Noyes S, Eldefrawy A, Ghali F, Meagher M, Hamilton Z, Yim K, Nasseri R, Bradshaw A, Dey S, Kirmiz S, Wan F, Liss M, Bensalah K, Montorsi F, Derweesh I. Oncologic and Functional Outcomes of Radical and Partial Nephrectomy in pT3a Pathologically Upstaged Renal Cell Carcinoma: A Multi-institutional Analysis. Clinical Genitourinary Cancer 2020, 18: e723-e729. PMID: 32600941, DOI: 10.1016/j.clgc.2020.05.002.Peer-Reviewed Original ResearchConceptsKaplan-Meier analysisRenal cell carcinomaPT3a renal cell carcinomaRecurrence-free survivalRadical nephrectomyPartial nephrectomyOverall survivalMultivariable analysisCell carcinomaFunctional outcomeDe novo eGFRGlomular filtration rateClinical T stageMulticenter retrospective analysisRisk of recurrenceMulti-institutional analysisPT3a upstagingOncologic outcomesSecondary outcomesPrimary outcomeIndependent predictorsSurvival outcomesT stagePositive marginsPredictive factorsMP82-16 SFI-UTUC, A NOVEL BASED MORPHOMETRIC SCORING SYSTEM FOR UPPER TRACT UROTHELIAL CELL CARCINOMA: PREDICTING SURVIVAL AND RECURRENCE OUTCOMES
Patel* D, Ghali F, Miller N, Patel S, Meagher M, Dutt R, Hamilton Z, Margulis V, Uzzo R, Derweesh I. MP82-16 SFI-UTUC, A NOVEL BASED MORPHOMETRIC SCORING SYSTEM FOR UPPER TRACT UROTHELIAL CELL CARCINOMA: PREDICTING SURVIVAL AND RECURRENCE OUTCOMES. Journal Of Urology 2020, 203 DOI: 10.1097/ju.0000000000000974.016.Peer-Reviewed Original ResearchPD45-02 EVALUATION OF RENAL CELL CARCINOMA INFLAMMATORY SCORE IN PATIENTS WITH LOCALIZED CLEAR CELL RENAL CELL CARCINOMA: AN INTERNATIONAL, MULTI-INSTITUTIONAL ANALYSIS
Patil* D, Medline A, Saito K, Lay A, Ghali F, Bilen M, Patel D, Pattaras J, Meagher M, Fukuda S, Yasuda Y, Fujii Y, Ogan K, Derweesh I, Master V. PD45-02 EVALUATION OF RENAL CELL CARCINOMA INFLAMMATORY SCORE IN PATIENTS WITH LOCALIZED CLEAR CELL RENAL CELL CARCINOMA: AN INTERNATIONAL, MULTI-INSTITUTIONAL ANALYSIS. Journal Of Urology 2020, 203 DOI: 10.1097/ju.0000000000000932.02.Peer-Reviewed Original ResearchUtilization of renal mass biopsy in patients with localized renal cell carcinoma: A population-based study utilizing the National Cancer Database.
Patel D, Ghali F, Patel S, Miller N, Bradshaw A, Meagher M, Rivera-Sanfeliz G, Murphy J, Derweesh I. Utilization of renal mass biopsy in patients with localized renal cell carcinoma: A population-based study utilizing the National Cancer Database. Journal Of Clinical Oncology 2020, 38: 662-662. DOI: 10.1200/jco.2020.38.6_suppl.662.Peer-Reviewed Original ResearchUse of RMBRenal cell carcinomaRenal mass biopsyNational Cancer DatabaseMultivariable logistic regressionTumor sizeCell carcinomaActive surveillanceCancer DatabaseMass biopsyLogistic regressionStudy periodCharlson Comorbidity IndexYear of diagnosisPopulation-based studyType of treatmentComorbidity indexSicker patientsBlack raceTumors 2Recent guidelinesTreatment strategiesPatientsAblation treatmentTumorsImpact of diabetes mellitus on functional and survival outcomes in renal cell carcinoma: An international multicenter study.
Dutt R, Meagher M, Patil D, Saito K, Patel D, Ghali F, Keiner C, Miller N, Bradshaw A, Wan F, Yasuda Y, Fujii Y, Master V, Derweesh I. Impact of diabetes mellitus on functional and survival outcomes in renal cell carcinoma: An international multicenter study. Journal Of Clinical Oncology 2020, 38: 666-666. DOI: 10.1200/jco.2020.38.6_suppl.666.Peer-Reviewed Original ResearchRenal cell carcinomaIndependent risk factorChronic kidney diseaseKaplan-Meier analysisRadical nephrectomyMultivariable analysisPartial nephrectomyRisk factorsPresence of DMFunctional declineDM statusOverall survivalKidney functionRCC patientsTumor sizeCell carcinomaRenal functional declineAfrican American raceInternational multicenter studyEffects of DMNDM patientsRN patientsCause mortalityWorse OSDiabetes mellitusDoes delay in time to surgery impact outcome in renal cell carcinoma: Analysis based on tumor size utilizing the National Cancer Database.
Patel D, Ghali F, Meagher M, Bradshaw A, Patel S, Murphy J, Derweesh I. Does delay in time to surgery impact outcome in renal cell carcinoma: Analysis based on tumor size utilizing the National Cancer Database. Journal Of Clinical Oncology 2020, 38: 664-664. DOI: 10.1200/jco.2020.38.6_suppl.664.Peer-Reviewed Original ResearchMultivariable Cox proportional hazardsNational Cancer DatabaseRenal cell carcinomaKaplan-Meier analysisYears of ageTumor sizeSurgery delayWorse OSOverall survivalHealthy patientsCell carcinomaCancer DatabaseLocalized Renal Cell CarcinomaNon-private insuranceTumor size 2Charlson comorbidity scoreCox proportional hazardsComorbidity scoreSurgical treatmentSurvival impactMedian timeEntire cohortFourth quartileBlack raceActive surveillance