2023
Health equity considerations in pragmatic trials in Alzheimer's and dementia disease: Results from a methodological review
Nicholls S, Al‐Jaishi A, Niznick H, Carroll K, Madani M, Peak K, Madani L, Nevins P, Adisso L, Li F, Weijer C, Mitchell S, Welch V, Quiñones A, Taljaard M. Health equity considerations in pragmatic trials in Alzheimer's and dementia disease: Results from a methodological review. Alzheimer's & Dementia Diagnosis Assessment & Disease Monitoring 2023, 15: e12392. PMID: 36777091, PMCID: PMC9899766, DOI: 10.1002/dad2.12392.Peer-Reviewed Original Research
2022
Ethical considerations within pragmatic randomized controlled trials in dementia: Results from a literature survey
Nicholls SG, Carroll K, Nix HP, Li F, Hey SP, Mitchell SL, Weijer C, Taljaard M. Ethical considerations within pragmatic randomized controlled trials in dementia: Results from a literature survey. Alzheimer's & Dementia: Translational Research & Clinical Interventions 2022, 8: e12287. PMID: 35509502, PMCID: PMC9060321, DOI: 10.1002/trc2.12287.Peer-Reviewed Original ResearchEthical considerationsEthical protectionsVulnerable participantsConsent approachResearch participantsResearch participationPatient's capacityAlzheimer's diseaseEthics approvalSearch of MEDLINEHealth care professionalsCapacity assessmentStudy populationEligible reportsTrial settingsConsentVulnerable groupsDementiaTwo-thirdsConsiderationDiseaseTrialsParticipantsExtracted informationMention
2021
A Bayesian approach for estimating the partial potential impact fraction with exposure measurement error under a main study/internal validation design
Chen X, Chang J, Spiegelman D, Li F. A Bayesian approach for estimating the partial potential impact fraction with exposure measurement error under a main study/internal validation design. Statistical Methods In Medical Research 2021, 31: 404-418. PMID: 34841964, DOI: 10.1177/09622802211060514.Peer-Reviewed Original ResearchConceptsPotential impact fractionImpact fractionExposure measurement errorHealth professionalsStudy designColorectal cancer incidenceValidation study designBurden of diseaseRisk factorsCancer incidenceHealth StudyDisease casesPublic health studiesRed meatContinuous exposureExposureProfessionalsIncidenceReclassification approachValidation designDiseaseIntakeMethodological challenges in pragmatic trials in Alzheimer’s disease and related dementias: Opportunities for improvement
Taljaard M, Li F, Qin B, Cui C, Zhang L, Nicholls SG, Carroll K, Mitchell SL. Methodological challenges in pragmatic trials in Alzheimer’s disease and related dementias: Opportunities for improvement. Clinical Trials 2021, 19: 86-96. PMID: 34841910, PMCID: PMC8847324, DOI: 10.1177/17407745211046672.Peer-Reviewed Original ResearchConceptsPragmatic trialAlzheimer's diseasePrimary outcomeSample size calculationGroup treatment trialsPairs of reviewersDementia researchSize calculationCluster Randomized TrialGroup treatment designRandomized trialsTreatment trialsIntracluster correlationMethodological qualityTrial reportsBaseline assessmentDiseaseTrialsDementiaKey methodological characteristicsOutcomesType IMethodological quality indicatorsUnique methodological challengesSame individualSample size and power considerations for cluster randomized trials with count outcomes subject to right truncation
Li F, Tong G. Sample size and power considerations for cluster randomized trials with count outcomes subject to right truncation. Biometrical Journal 2021, 63: 1052-1071. PMID: 33751620, PMCID: PMC9132617, DOI: 10.1002/bimj.202000230.Peer-Reviewed Original ResearchConceptsCluster Randomized TrialPrimary outcomeGroup-based interventionRandomized trialsHealth StudySuch trialsPublic health studiesRight truncationTrialsOutcomesVector-borne diseasesCountSample size formulaAnalysis of CRTsPower calculationPopulation-level effectsSample sizeSize formulaClosed-form sample size formulaMarginal modeling approachMalariaDisease
2020
Statistical Considerations for Embedded Pragmatic Clinical Trials in People Living with Dementia
Allore HG, Goldfeld KS, Gutman R, Li F, Monin JK, Taljaard M, Travison TG. Statistical Considerations for Embedded Pragmatic Clinical Trials in People Living with Dementia. Journal Of The American Geriatrics Society 2020, 68: s68-s73. PMID: 32589276, PMCID: PMC7396162, DOI: 10.1111/jgs.16616.Peer-Reviewed Original ResearchConceptsEmbedded Pragmatic Clinical TrialsPragmatic clinical trialsClinical trialsAlzheimer's diseaseImbedded Pragmatic Alzheimer's DiseaseIMPACT CollaboratoryOutcome ascertainmentPoint of careNonpharmacological interventionsReal-world settingComplex interventionsTrialsIntervention effectivenessVulnerable populationsPragmatic designHealthcare systemNational InstituteClinical scientistsSuch interventionsInterventionDementiaPLWDDiseaseCaregiversResearch priorities