Formation of somatosensory detour circuits mediates functional recovery following dorsal column injury
Granier C, Schwarting J, Fourli E, Laage-Gaupp F, Hennrich AA, Schmalz A, Jacobi A, Wesolowski M, Conzelmann KK, Bareyre FM. Formation of somatosensory detour circuits mediates functional recovery following dorsal column injury. Scientific Reports 2020, 10: 10953. PMID: 32616790, PMCID: PMC7331809, DOI: 10.1038/s41598-020-67866-x.Peer-Reviewed Original ResearchConceptsDetour circuitsDorsal root gangliaFunctional recoveryProprioceptive functionDorsal column-medial lemniscus pathwayUnilateral dorsal column lesionsIncomplete spinal cord injuryDorsal column injuryDorsal column lesionSpinal gray matterSpinal cord injurySpinal cord neuronsAxonal rewiringSensory fibersCord injuryColumn injuryCord neuronsRoot gangliaCuneate nucleusInitial remodelingMonosynaptic circuitSpinal networksAdult miceDRG axonsGray matter