Iron acquisition by a commensal bacterium modifies host nutritional immunity during Salmonella infection
Spiga L, Fansler R, Perera Y, Shealy N, Munneke M, David H, Torres T, Lemoff A, Ran X, Richardson K, Pudlo N, Martens E, Folta-Stogniew E, Yang Z, Skaar E, Byndloss M, Chazin W, Zhu W. Iron acquisition by a commensal bacterium modifies host nutritional immunity during Salmonella infection. Cell Host & Microbe 2023, 31: 1639-1654.e10. PMID: 37776864, PMCID: PMC10599249, DOI: 10.1016/j.chom.2023.08.018.Peer-Reviewed Original ResearchConceptsLipocalin-2Nutritional immunityProtein lipocalin 2Role of commensalIntestinal inflammationInflamed gutSalmonella infectionHost nutritional immunityImmunityGut bacteriaIron metabolismHost-pathogen interactionsGut commensal Bacteroides thetaiotaomicronPathogensBacteroides thetaiotaomicronSalmonellaInflammationInfectionHost sequestration