Tuning protein half-life in mouse using sequence-defined biopolymers functionalized with lipids
Vanderschuren K, Arranz-Gibert P, Khang M, Hadar D, Gaudin A, Yang F, Folta-Stogniew E, Saltzman WM, Amiram M, Isaacs FJ. Tuning protein half-life in mouse using sequence-defined biopolymers functionalized with lipids. Proceedings Of The National Academy Of Sciences Of The United States Of America 2022, 119: e2103099119. PMID: 35046019, PMCID: PMC8794819, DOI: 10.1073/pnas.2103099119.Peer-Reviewed Original ResearchConceptsSequence-defined biopolymersProtein-based drugsModel fusion proteinProof of conceptSynthetic biopolymersBroad applicationsMaterials scienceProgrammable approachLow toxicityHigh specificityPeptide therapeuticsBiopolymersLimited side effectsConjugation sitesBlood serumBiotechnologyTechnical foundationFusion proteinMouse serumBiophysical propertiesAzidophenylalanineApplicationsPast decadeTherapeutics