2017
Reduced Cerebrovascular Reactivity and Increased Resting Cerebral Perfusion in Rats Exposed to a Cafeteria Diet
Gomez-Smith M, Janik R, Adams C, Lake EM, Thomason LAM, Jeffers MS, Stefanovic B, Corbett D. Reduced Cerebrovascular Reactivity and Increased Resting Cerebral Perfusion in Rats Exposed to a Cafeteria Diet. Neuroscience 2017, 371: 166-177. PMID: 29229555, DOI: 10.1016/j.neuroscience.2017.11.054.Peer-Reviewed Original ResearchConceptsRat endothelial cell antigen-1Cerebrovascular reactivityCafeteria dietMagnetic resonance imagingCerebral perfusionStandard chowAnimals fed standard chowEndothelial cell antigen-1Arterial spin labeling magnetic resonance imagingContinuous arterial spin labeling (CASL) magnetic resonance imagingEndothelin-1 injectionReduced Cerebrovascular ReactivityUltra-processed dietFed standard chowSprague-Dawley ratsShort-term consumptionCell antigen-1CAF ratsCerebrovascular functionIschemic lesionsCerebral microvasculatureDiet ratsSensorimotor cortexBrain perfusionDawley rats
2016
Modulation of the peri‐infarct neurogliovascular function by delayed COX‐1 inhibition
Lake EMR, Mester J, Thomason LA, Adams C, Bazzigaluppi P, Koletar M, Janik R, Carlen P, McLaurin J, Stanisz GJ, Stefanovic B. Modulation of the peri‐infarct neurogliovascular function by delayed COX‐1 inhibition. Journal Of Magnetic Resonance Imaging 2016, 46: 505-517. PMID: 28703413, DOI: 10.1002/jmri.25541.Peer-Reviewed Original ResearchConceptsNeuronal survivalMicroglia/macrophage recruitmentExerts multiple beneficial effectsChronic ischemic injuryAdult male ratsCOX-1 inhibitionMultiple beneficial effectsMost patientsAstrocytic activationEndothelial densityNeuronal lossChronic stageFocal ischemiaHemodynamic changesIschemic injuryAdult disabilityMacrophage recruitmentMale ratsPerfusion responseMore effective interventionsNeurogliovascular unitCOX-1Novel treatmentsPerfusionBeneficial effectsFunctional magnetic resonance imaging in chronic ischaemic stroke
Lake EM, Bazzigaluppi P, Stefanovic B. Functional magnetic resonance imaging in chronic ischaemic stroke. Philosophical Transactions Of The Royal Society B Biological Sciences 2016, 371: 20150353. PMID: 27574307, PMCID: PMC5003855, DOI: 10.1098/rstb.2015.0353.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingIschemic strokeInjury progressionLevel-dependent functional magnetic resonance imagingBlood oxygenation level-dependent functional magnetic resonance imagingChronic ischemic strokeBOLD functional magnetic resonance imagingBOLD signal contrastMagnetic resonance imagingFunctional magnetic resonanceBOLD fMRI measurementsVascular reactivityStroke progressionAdult disabilityChronic stageVascular functionPreclinical modelsStroke researchNeuronal activityNew treatmentsResonance imagingVivo markerClinical researchPreclinical researchBrain functionNeurovascular unit remodelling in the subacute stage of stroke recovery
Lake EMR, Bazzigaluppi P, Mester J, Thomason LAM, Janik R, Brown M, McLaurin J, Carlen PL, Corbett D, Stanisz GJ, Stefanovic B. Neurovascular unit remodelling in the subacute stage of stroke recovery. NeuroImage 2016, 146: 869-882. PMID: 27664828, DOI: 10.1016/j.neuroimage.2016.09.016.Peer-Reviewed Original ResearchConceptsPeri-lesional cortexVascular reactivityNeuronal lossSubacute stageEndothelin-1LFP activityLong-term functional outcomeLocal field potential responsesPeripheral somatosensory stimulationActivation of microgliaET-1 injectionFocal ischemic strokeFocal cerebral ischaemiaPeri-infarct zoneSensori-motor cortexSpontaneous neuronal activityAdult Sprague-DawleyField potential responsesExtended temporal windowDynamic functional changesIschemic strokeAstrocytic activationCerebral ischaemiaNeurovascular unitIschemic insult
2015
The Effects of Delayed Reduction of Tonic Inhibition on Ischemic Lesion and Sensorimotor Function
Lake E, Chaudhuri J, Thomason L, Janik R, Ganguly M, Brown M, McLaurin J, Corbett D, Stanisz GJ, Stefanovic B. The Effects of Delayed Reduction of Tonic Inhibition on Ischemic Lesion and Sensorimotor Function. Cerebrovascular And Brain Metabolism Reviews 2015, 35: 1601-1609. PMID: 25966952, PMCID: PMC4640317, DOI: 10.1038/jcbfm.2015.86.Peer-Reviewed Original ResearchConceptsIschemic lesionsFocal ischemiaEndothelin-1Rat modelMontoya staircase testWeeks of treatmentTotal stroke volumeCortical microinjectionsIschemic strokeChronic stageSensorimotor deficitsStroke recoveryTonic inhibitionSensorimotor functionStroke volumeGABAA antagonismGABA antagonismStaircase testPerilesional regionsDelayed reductionInverse agonistNecrotic coreBrain structuresBeneficial effectsStroke