Featured Publications
Perivascular Fat Attenuation Index Stratifies Cardiac Risk Associated With High-Risk Plaques in the CRISP-CT Study
Oikonomou EK, Desai MY, Marwan M, Kotanidis CP, Antonopoulos AS, Schottlander D, Channon KM, Neubauer S, Achenbach S, Antoniades C. Perivascular Fat Attenuation Index Stratifies Cardiac Risk Associated With High-Risk Plaques in the CRISP-CT Study. Journal Of The American College Of Cardiology 2020, 76: 755-757. PMID: 32762910, DOI: 10.1016/j.jacc.2020.05.078.Peer-Reviewed Original ResearchNon-invasive detection of coronary inflammation using computed tomography and prediction of residual cardiovascular risk (the CRISP CT study): a post-hoc analysis of prospective outcome data
Oikonomou EK, Marwan M, Desai MY, Mancio J, Alashi A, Centeno E, Thomas S, Herdman L, Kotanidis CP, Thomas KE, Griffin BP, Flamm SD, Antonopoulos AS, Shirodaria C, Sabharwal N, Deanfield J, Neubauer S, Hopewell JC, Channon KM, Achenbach S, Antoniades C. Non-invasive detection of coronary inflammation using computed tomography and prediction of residual cardiovascular risk (the CRISP CT study): a post-hoc analysis of prospective outcome data. The Lancet 2018, 392: 929-939. PMID: 30170852, PMCID: PMC6137540, DOI: 10.1016/s0140-6736(18)31114-0.Peer-Reviewed Original ResearchMeSH KeywordsAdipocytesAdipose TissueAdolescentAdultAgedAged, 80 and overComputed Tomography AngiographyCoronary AngiographyCoronary Artery DiseaseCoronary VesselsFemaleFollow-Up StudiesHumansImaging, Three-DimensionalMaleMiddle AgedPlaque, AtheroscleroticPredictive Value of TestsProportional Hazards ModelsProspective StudiesRisk AssessmentSurvival AnalysisYoung AdultConceptsRight coronary arteryProximal right coronary arteryCardiac mortalityCoronary inflammationCoronary CTACoronary arteryDerivation cohortValidation cohortOutcome dataHealth Research Oxford Biomedical Research CentreCoronary artery disease indexHigh-risk plaque featuresPerivascular fat attenuation indexCoronary artery inflammationFat attenuation indexIntensive secondary preventionCardiovascular risk factorsResidual cardiovascular riskProspective outcome dataMajor coronary arteriesHounsfield unitsLeft circumflex arteryCox regression modelRisk predictionCardiac risk prediction
2023
Use of Wearable Devices in Individuals With or at Risk for Cardiovascular Disease in the US, 2019 to 2020
Dhingra L, Aminorroaya A, Oikonomou E, Nargesi A, Wilson F, Krumholz H, Khera R. Use of Wearable Devices in Individuals With or at Risk for Cardiovascular Disease in the US, 2019 to 2020. JAMA Network Open 2023, 6: e2316634. PMID: 37285157, PMCID: PMC10248745, DOI: 10.1001/jamanetworkopen.2023.16634.Peer-Reviewed Original ResearchConceptsHealth Information National Trends SurveyUS adultsExacerbate disparitiesWearable device usersCardiovascular diseaseCardiovascular healthPopulation-based cross-sectional studySelf-reported cardiovascular diseaseCardiovascular disease risk factorsNational Trends SurveyOverall US adult populationCardiovascular risk factor profileSelf-reported accessAssociated with lower useUse of wearable devicesImprove cardiovascular healthLower household incomeLower educational attainmentUS adult populationRisk factor profileNationally representative sampleCross-sectional studyProportion of adultsTrends SurveyWearable device data
2022
The impact of induction therapy on mortality and treated rejection in cardiac transplantation: A retrospective study
Bellumkonda L, Oikonomou EK, Hsueh C, Maulion C, Testani J, Patel J. The impact of induction therapy on mortality and treated rejection in cardiac transplantation: A retrospective study. The Journal Of Heart And Lung Transplantation 2022, 41: 482-491. PMID: 35094919, DOI: 10.1016/j.healun.2022.01.008.Peer-Reviewed Original ResearchConceptsInduction therapyCause mortalityOutcome measuresLeft ventricular assist device therapyT-cell depleting agentsVentricular assist device therapyDual organ transplantsRoutine induction therapySecondary outcome measuresTime of transplantationPrimary outcome measureCox regression modelPropensity score adjustmentRisk of rejectionPrior transplantCardiac transplantationHeart transplantationUNOS databaseAdult patientsOverall survivalDevice therapyMedian ageRetrospective studyReceptor antagonistReduced odds
2021
Standardized measurement of coronary inflammation using cardiovascular computed tomography: integration in clinical care as a prognostic medical device
Oikonomou EK, Antonopoulos AS, Schottlander D, Marwan M, Mathers C, Tomlins P, Siddique M, Klüner LV, Shirodaria C, Mavrogiannis MC, Thomas S, Fava A, Deanfield J, Channon KM, Neubauer S, Desai MY, Achenbach S, Antoniades C. Standardized measurement of coronary inflammation using cardiovascular computed tomography: integration in clinical care as a prognostic medical device. Cardiovascular Research 2021, 117: 2677-2690. PMID: 34450625, DOI: 10.1093/cvr/cvab286.Peer-Reviewed Original ResearchMeSH KeywordsAdipose TissueAdiposityAdolescentAdultAgedAged, 80 and overAlgorithmsCloud ComputingComputed Tomography AngiographyCoronary AngiographyCoronary Artery DiseaseCoronary VesselsDecision Support TechniquesEnglandFemaleGermanyHeart Disease Risk FactorsHumansInflammationMaleMiddle AgedNomogramsOhioPredictive Value of TestsPrognosisRisk AssessmentTime FactorsYoung AdultConceptsFat attenuation indexPerivascular fat attenuation indexRisk factor-based modelCoronary artery inflammationClinical risk factorsFatal cardiac eventsCoronary artery diseaseCoronary inflammationRisk factorsFAI scorePlaque metricsCardiac eventsArtery inflammationAbsolute riskCoronary arteryClinical careNon-invasive detectionTraditional cardiovascular risk factorsPatient's absolute riskCardiovascular risk factorsFat compositionNet clinical benefitCardiovascular risk predictionDecision curve analysisFirst-line modality
2019
Development of a risk score for early saphenous vein graft failure: An individual patient data meta-analysis
Antonopoulos AS, Odutayo A, Oikonomou EK, Trivella M, Petrou M, Collins GS, Antoniades C, group S, Akoumianakis I, Channon K, Herdman L, Margaritis M, Neubauer S, Thomas S, Fremes S, Karkhanis R, Rade J, Fukui T, Nishida H, Takanashi S, Hwang H, Kim K, Mannacio L, Mannacio V, Nakano J, Perrault L, Kardos A, Okabayashi H, Tousoulis D, Kelion A, Sabharwal N, Krasopoulos G, Sayeed R, Taggart D. Development of a risk score for early saphenous vein graft failure: An individual patient data meta-analysis. Journal Of Thoracic And Cardiovascular Surgery 2019, 160: 116-127.e4. PMID: 31606176, PMCID: PMC7322547, DOI: 10.1016/j.jtcvs.2019.07.086.Peer-Reviewed Original ResearchConceptsEarly SVG occlusionIndividual patient dataSVG occlusionRisk scoreValidation cohortEarly saphenous vein graft failureEarly saphenous vein graft occlusionSaphenous vein graft failureSaphenous vein graft occlusionAggressive treatment strategiesPatient dataVein graft occlusionNovel risk scoreVein graft failureRisk score systemGraft failureGraft occlusionOperative characteristicsTreatment strategiesIndividualized riskOperative factorsScore systemOcclusionExternal validationCohort
2018
Development and Validation of a Clinical Score for Cardiovascular Risk Stratification of Long‐Term Childhood Cancer Survivors
Oikonomou EK, Athanasopoulou SG, Kampaktsis PN, Kokkinidis DG, Papanastasiou CA, Feher A, Steingart RM, Oeffinger KC, Gupta D. Development and Validation of a Clinical Score for Cardiovascular Risk Stratification of Long‐Term Childhood Cancer Survivors. The Oncologist 2018, 23: 965-973. PMID: 29593100, PMCID: PMC6156177, DOI: 10.1634/theoncologist.2017-0502.Peer-Reviewed Original ResearchConceptsLong-term childhood cancer survivorsChildhood cancer survivorsCardiovascular risk stratificationCardiovascular mortalityCancer survivorsRisk scoreCardiovascular riskRisk stratificationRisk of CVMTreatment-related adverse eventsAdverse cardiovascular eventsRisk stratification toolSimple risk scoreCongestive heart failureCumulative incidence rateEnd Results ProgramMedian time periodPopulation-based studyHistory of lymphomaHigh-risk groupLow-risk groupSimple clinical toolHistory of radiationNon-white raceHealth care providers
2017
Vascular inflammation and metabolic activity in hematopoietic organs and liver in familial combined hyperlipidemia and heterozygous familial hypercholesterolemia
Toutouzas K, Skoumas J, Koutagiar I, Benetos G, Pianou N, Georgakopoulos A, Galanakos S, Antonopoulos A, Drakopoulou M, Oikonomou EK, Kafouris P, Athanasiadis E, Metaxas M, Spyrou G, Pallantza Z, Galiatsatos N, Aggeli C, Antoniades C, Keramida G, Peters AM, Anagnostopoulos CD, Tousoulis D. Vascular inflammation and metabolic activity in hematopoietic organs and liver in familial combined hyperlipidemia and heterozygous familial hypercholesterolemia. Journal Of Clinical Lipidology 2017, 12: 33-43. PMID: 29174439, DOI: 10.1016/j.jacl.2017.10.019.Peer-Reviewed Original ResearchMeSH KeywordsAdultBiomarkersBone MarrowCase-Control StudiesC-Reactive ProteinFemaleHeterozygoteHumansHydroxymethylglutaryl-CoA Reductase InhibitorsHyperlipidemia, Familial CombinedHyperlipoproteinemia Type IIInflammationLipoproteins, LDLLiverMaleMiddle AgedPositron Emission Tomography Computed TomographySpleenConceptsHeFH patientsFDG uptakeAortic TBRVascular inflammationBone marrowFamilial dyslipidemiaHigher low-density lipoprotein levelsF-fluorodeoxyglucose positron emission tomography/High-sensitivity C-reactive proteinBone marrow FDG uptakeLow-density lipoprotein levelsPositron emission tomography/C-reactive proteinHigh FDG uptakeHeterozygous familial hypercholesterolemiaLow-density lipoproteinHepatic metabolic activityHematopoietic organsHigh liver uptakeDyslipidemic groupAdult patientsCardiovascular riskInflammatory biomarkersSerum lipidsAccelerated atherogenesis