2020
Insulin-induced vascular redox dysregulation in human atherosclerosis is ameliorated by dipeptidyl peptidase 4 inhibition
Akoumianakis I, Badi I, Douglas G, Chuaiphichai S, Herdman L, Akawi N, Margaritis M, Antonopoulos AS, Oikonomou EK, Psarros C, Galiatsatos N, Tousoulis D, Kardos A, Sayeed R, Krasopoulos G, Petrou M, Schwahn U, Wohlfart P, Tennagels N, Channon KM, Antoniades C. Insulin-induced vascular redox dysregulation in human atherosclerosis is ameliorated by dipeptidyl peptidase 4 inhibition. Science Translational Medicine 2020, 12 PMID: 32350133, PMCID: PMC7212010, DOI: 10.1126/scitranslmed.aav8824.Peer-Reviewed Original ResearchConceptsDipeptidyl peptidase-4 inhibitorsCoronary artery bypass surgeryAggressive insulin treatmentInsulin treatmentCoronary atherosclerosisEndothelial functionAbnormal responseHigh-fat diet-fed ApoEOral dipeptidyl peptidase-4 inhibitorLong-term combination therapyHuman internal mammary arteryDipeptidyl peptidase-4 inhibitionHigher cardiac mortalityPeptidase-4 inhibitionVascular insulin responsesVascular redox stateArtery bypass surgeryInternal mammary arteryInsulin resistance statusNitric oxide bioavailabilityPeptidase-4 inhibitorsPlasma DPP4 activityVascular oxidative stressRecent clinical trialsInsulin-sensitizing effects
2015
The role of microRNAs in coronary artery disease: From pathophysiology to diagnosis and treatment
Economou EK, Oikonomou E, Siasos G, Papageorgiou N, Tsalamandris S, Mourouzis K, Papaioanou S, Tousoulis D. The role of microRNAs in coronary artery disease: From pathophysiology to diagnosis and treatment. Atherosclerosis 2015, 241: 624-633. PMID: 26117399, DOI: 10.1016/j.atherosclerosis.2015.06.037.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsAnimalsApoptosisAtherosclerosisBiomarkersBlood PlateletsCell MovementCoronary Artery DiseaseDisease ProgressionEndothelium, VascularGene Expression RegulationHumansLipoproteins, HDLLipoproteins, LDLMiceMicroRNAsMonocytesMuscle, Smooth, VascularMyocardial InfarctionNeovascularization, PathologicOligonucleotidesReperfusion InjuryStem CellsConceptsCoronary artery diseaseDevelopment of atherosclerosisArtery diseaseCoronary artery disease progressionPathogenesis of atherosclerosisStudy of miRNAsMyocardial infarctionDisease progressionSpecific miRNA expression patternsTherapeutic approachesRole of microRNAsPreventive opportunitiesDiagnostic biomarkersRelated conditionsAtherosclerosisMiRNA expression patternsDiseaseNon-coding RNA moleculesRole of miRNAsIntercellular communicationIntracellular regulatorsExpression patternsMiRNAsPost-transcriptional levelGene expression