Featured Publications
A phenomapping-derived tool to personalize the selection of anatomical vs. functional testing in evaluating chest pain (ASSIST)
Oikonomou EK, Van Dijk D, Parise H, Suchard MA, de Lemos J, Antoniades C, Velazquez EJ, Miller EJ, Khera R. A phenomapping-derived tool to personalize the selection of anatomical vs. functional testing in evaluating chest pain (ASSIST). European Heart Journal 2021, 42: 2536-2548. PMID: 33881513, PMCID: PMC8488385, DOI: 10.1093/eurheartj/ehab223.Peer-Reviewed Original ResearchConceptsStable chest painChest painPrimary endpointMajor adverse cardiovascular eventsNon-fatal myocardial infarctionAdverse cardiovascular eventsStudy's primary endpointCoronary artery diseaseClinical trial populationsCox regression modelParticipant-level dataSCOT-HEARTCardiovascular eventsCause mortalityHazard ratioPatients 5Artery diseaseFunctional testingPROMISE trialTrial populationMyocardial infarctionLower incidenceStudy populationPainCollected variables
2020
Pericoronary fat radiomic profile (FRP) predicts long-term cardiac risk in individuals with calcium score below 100 on coronary computed tomography angiography
Kotanidis C, Oikonomou E, Williams M, Thomas S, Thomas K, Lyasheva M, Antonopoulos A, Dweck M, Shirodaria C, Neubauer S, Channon K, Newby D, Antoniades C. Pericoronary fat radiomic profile (FRP) predicts long-term cardiac risk in individuals with calcium score below 100 on coronary computed tomography angiography. European Heart Journal 2020, 41: ehaa946.0181. DOI: 10.1093/ehjci/ehaa946.0181.Peer-Reviewed Original ResearchCoronary artery calciumCoronary artery diseaseHigh-risk plaquesAdipose tissue compositionArtery calciumCAC scoreCardiac riskTomography angiographyStudy populationLong-term cardiac riskMajor adverse cardiac eventsObstructive coronary artery diseaseSCOT-HEART trialAdverse cardiac eventsRisk of MACEAdverse clinical eventsTraditional risk factorsChronic vascular inflammationLow CAC scoresPericoronary adipose tissueCardiovascular risk assessmentLow-risk populationCox regression modelBritish Heart FoundationBiomedical Research Centre