Featured Publications
A Multimodal Video-Based AI Biomarker for Aortic Stenosis Development and Progression
Oikonomou E, Holste G, Yuan N, Coppi A, McNamara R, Haynes N, Vora A, Velazquez E, Li F, Menon V, Kapadia S, Gill T, Nadkarni G, Krumholz H, Wang Z, Ouyang D, Khera R. A Multimodal Video-Based AI Biomarker for Aortic Stenosis Development and Progression. JAMA Cardiology 2024, 9: 534-544. PMID: 38581644, PMCID: PMC10999005, DOI: 10.1001/jamacardio.2024.0595.Peer-Reviewed Original ResearchCardiac magnetic resonanceAortic valve replacementCardiac magnetic resonance imagingAV VmaxSevere ASAortic stenosisCohort studyPeak aortic valve velocityCohort study of patientsAortic valve velocityCohort of patientsTraditional cardiovascular risk factorsAssociated with faster progressionStudy of patientsCedars-Sinai Medical CenterAssociated with AS developmentCardiovascular risk factorsCardiovascular imaging modalitiesIndependent of ageModerate ASEjection fractionEchocardiographic studiesValve replacementRisk stratificationCardiac structureThe role of adipose tissue in cardiovascular health and disease
Oikonomou EK, Antoniades C. The role of adipose tissue in cardiovascular health and disease. Nature Reviews Cardiology 2018, 16: 83-99. PMID: 30287946, DOI: 10.1038/s41569-018-0097-6.BooksConceptsAdipose tissueCardiovascular systemCardiovascular healthInsulin resistance leadPro-atherogenic profileCardiovascular risk stratificationAdipose tissue functionAdipose tissue biologyComplex homeostatic mechanismsRisk stratificationLocal inflammationCardiovascular diseasePossible clinical translationParacrine effectsTherapeutic targetingHomeostatic mechanismsDiseaseGaseous messengerTissueClinical translationTissue biologyTissue functionCrucial regulatorCurrent knowledgeHealth
2021
D Radiotranscriptomic analysis of perivascular adipose tissue quantifies vascular inflammation in covid-19 from routine CT angiograms: Stratification of “new UK variant” Infection and prediction of in-hospital outcomes
Kotanidis C, Xie C, Adlam D, Rodrigues J, Siddique M, Lockstone H, Thomas S, Kotronias R, Oikonomou E, Lumley S, Neubauer S, Newby D, Channon K, Deanfield J, Antoniades C. D Radiotranscriptomic analysis of perivascular adipose tissue quantifies vascular inflammation in covid-19 from routine CT angiograms: Stratification of “new UK variant” Infection and prediction of in-hospital outcomes. Heart 2021, 107: a177-a178. DOI: 10.1136/heartjnl-2021-bcs.238.Peer-Reviewed Original ResearchCT pulmonary angiogramComputed tomography angiographyHigher vascular inflammationVascular inflammationCOVID-19 infectionHospital mortalityPrognostic valueCOVID-19Acute COVID-19 infectionExternal testing cohortAnti-inflammatory treatmentInternal mammary arteryPerivascular adipose tissueCOVID-19 patientsVascular inflammatory responseUK variantSARS-CoV-2Novel imaging biomarkersHospital outcomesMammary arteryPulmonary angiogramArterial inflammationHazard ratioClinical factorsRisk stratificationStandardised quantification of coronary inflammation using cardiac computed tomography: The Fat Attenuation Index Score (FAI-Score)
Oikonomou E, Schottlander D, Antonopoulos A, Marwan M, Kotanidis C, Kluner L, Shirodaria C, Channon K, Neubauer S, Desai M, Deanfield J, Achenbach S, Antoniades C. Standardised quantification of coronary inflammation using cardiac computed tomography: The Fat Attenuation Index Score (FAI-Score). European Journal Of Preventive Cardiology 2021, 28: zwab061.451. DOI: 10.1093/eurjpc/zwab061.451.Peer-Reviewed Original ResearchCoronary inflammationRight coronaryFAI scoreCardiac mortalityPercentile curvesPrognostic valueCoronary artery disease indexHigh-risk plaque featuresCardiovascular prevention strategiesTraditional risk factorsCardiac computed tomographyBritish Heart FoundationFAI valuesMedian followInflammatory burdenCardiovascular riskAtherosclerotic changesCardiac deathAnterior descendingCircumflex arteryCoronary territoriesRisk stratificationPlaque featuresCoronary arteryMean age
2020
OP3 Improved cardiac risk stratification in individuals with high risk plaque features using the perivascular fat attenuation index on CCTA
Kotanidis C, Oikonomou E, Marwan M, Kluener L, Thomas K, Alashi A, Antonopoulos A, Shirodaria C, Neubauer S, Channon K, Achenbach S, Desai M, Antoniades C. OP3 Improved cardiac risk stratification in individuals with high risk plaque features using the perivascular fat attenuation index on CCTA. Heart 2020, 106: a1-a2. DOI: 10.1136/heartjnl-2020-bsci.3.Peer-Reviewed Original ResearchFat attenuation indexHigh-risk plaquesPerivascular fat attenuation indexAdjusted riskCardiac riskHRP featuresHigh-risk plaque featuresMajor adverse cardiac eventsProximal right coronary arteryAdditive predictive valueAdverse cardiac eventsLow-attenuation plaqueRight coronary arteryCardiac risk stratificationCox regression modelNapkin-ring signAdipose tissue compositionCoronary inflammationCardiac mortalityInflammatory burdenCardiac eventsSpotty calcificationRisk stratificationPlaque featuresCoronary arteryArtificial intelligence in medical imaging: A radiomic guide to precision phenotyping of cardiovascular disease
Oikonomou EK, Siddique M, Antoniades C. Artificial intelligence in medical imaging: A radiomic guide to precision phenotyping of cardiovascular disease. Cardiovascular Research 2020, 116: 2040-2054. PMID: 32090243, PMCID: PMC7585409, DOI: 10.1093/cvr/cvaa021.Peer-Reviewed Original ResearchConceptsCardiac computed tomographyNon-invasive imagingCardiovascular imagingCardiovascular diseaseNon-invasive cardiovascular imagingCardiac CTCardiovascular risk stratificationFirst-line optionImportant clinical implicationsRisk stratificationUnstable patientsClinical careComputed tomographyCurrent evidenceClinical implicationsCardiac imagingRadiomics approachPatientsRadiomics methodTissue biologyCardiovascular diagnosticsDiseaseFuture studiesImagingPhenotyping