Featured Publications
Assessment of Prognostic Value of Left Ventricular Global Longitudinal Strain for Early Prediction of Chemotherapy-Induced Cardiotoxicity
Oikonomou EK, Kokkinidis DG, Kampaktsis PN, Amir EA, Marwick TH, Gupta D, Thavendiranathan P. Assessment of Prognostic Value of Left Ventricular Global Longitudinal Strain for Early Prediction of Chemotherapy-Induced Cardiotoxicity. JAMA Cardiology 2019, 4: 1007-1018. PMID: 31433450, PMCID: PMC6705141, DOI: 10.1001/jamacardio.2019.2952.Peer-Reviewed Original ResearchConceptsCancer therapy-related cardiac dysfunctionGlobal longitudinal strainLeft ventricular global longitudinal strainVentricular global longitudinal strainPrognostic valueCutoff valuePublication biasMeasurement of GLSNew-onset heart failure symptomsAbsolute global longitudinal strainWorse global longitudinal strainLarge prospective multicenter studyLeft ventricular ejection fractionDiscriminatory performanceLongitudinal strainChemotherapy-Induced CardiotoxicityGLS cutoff valueSubclinical ventricular dysfunctionHeart failure symptomsProspective multicenter studyVentricular ejection fractionCochrane Library databasesRisk of biasOptimal cutoff valueBetter prognostic performance
2021
Impaired Myocardial Flow Reserve on 82Rubidium Positron Emission Tomography/Computed Tomography in Patients With Systemic Sclerosis.
Feher A, Boutagy NE, Oikonomou EK, Thorn S, Liu YH, Miller EJ, Sinusas AJ, Hinchcliff M. Impaired Myocardial Flow Reserve on 82Rubidium Positron Emission Tomography/Computed Tomography in Patients With Systemic Sclerosis. The Journal Of Rheumatology 2021, 48: 1574-1582. PMID: 34266986, PMCID: PMC10275580, DOI: 10.3899/jrheum.210040.Peer-Reviewed Original ResearchConceptsReduced Myocardial Flow ReserveMyocardial flow reserveRaynaud's phenomenonPrimary Raynaud's phenomenonSecondary Raynaud's phenomenonPatient controlsHealthy participantsFlow reservePositron Emission Tomography/Computed TomographyEmission Tomography/Computed TomographyTomography/Computed TomographyPositron emission tomography/Impaired Myocardial Flow ReserveCoronary microvascular dysfunctionLarge prospective studiesMultivariable logistic regressionEmission tomography/PET/CTSSc-RPMicrovascular dysfunctionClinical predictorsIndependent predictorsSystemic sclerosisPrognostic valueProspective studyD Radiotranscriptomic analysis of perivascular adipose tissue quantifies vascular inflammation in covid-19 from routine CT angiograms: Stratification of “new UK variant” Infection and prediction of in-hospital outcomes
Kotanidis C, Xie C, Adlam D, Rodrigues J, Siddique M, Lockstone H, Thomas S, Kotronias R, Oikonomou E, Lumley S, Neubauer S, Newby D, Channon K, Deanfield J, Antoniades C. D Radiotranscriptomic analysis of perivascular adipose tissue quantifies vascular inflammation in covid-19 from routine CT angiograms: Stratification of “new UK variant” Infection and prediction of in-hospital outcomes. Heart 2021, 107: a177-a178. DOI: 10.1136/heartjnl-2021-bcs.238.Peer-Reviewed Original ResearchCT pulmonary angiogramComputed tomography angiographyHigher vascular inflammationVascular inflammationCOVID-19 infectionHospital mortalityPrognostic valueCOVID-19Acute COVID-19 infectionExternal testing cohortAnti-inflammatory treatmentInternal mammary arteryPerivascular adipose tissueCOVID-19 patientsVascular inflammatory responseUK variantSARS-CoV-2Novel imaging biomarkersHospital outcomesMammary arteryPulmonary angiogramArterial inflammationHazard ratioClinical factorsRisk stratificationStandardised quantification of coronary inflammation using cardiac computed tomography: The Fat Attenuation Index Score (FAI-Score)
Oikonomou E, Schottlander D, Antonopoulos A, Marwan M, Kotanidis C, Kluner L, Shirodaria C, Channon K, Neubauer S, Desai M, Deanfield J, Achenbach S, Antoniades C. Standardised quantification of coronary inflammation using cardiac computed tomography: The Fat Attenuation Index Score (FAI-Score). European Journal Of Preventive Cardiology 2021, 28: zwab061.451. DOI: 10.1093/eurjpc/zwab061.451.Peer-Reviewed Original ResearchCoronary inflammationRight coronaryFAI scoreCardiac mortalityPercentile curvesPrognostic valueCoronary artery disease indexHigh-risk plaque featuresCardiovascular prevention strategiesTraditional risk factorsCardiac computed tomographyBritish Heart FoundationFAI valuesMedian followInflammatory burdenCardiovascular riskAtherosclerotic changesCardiac deathAnterior descendingCircumflex arteryCoronary territoriesRisk stratificationPlaque featuresCoronary arteryMean age