2021
Standardised quantification of coronary inflammation using cardiac computed tomography: The Fat Attenuation Index Score (FAI-Score)
Oikonomou E, Schottlander D, Antonopoulos A, Marwan M, Kotanidis C, Kluner L, Shirodaria C, Channon K, Neubauer S, Desai M, Deanfield J, Achenbach S, Antoniades C. Standardised quantification of coronary inflammation using cardiac computed tomography: The Fat Attenuation Index Score (FAI-Score). European Journal Of Preventive Cardiology 2021, 28: zwab061.451. DOI: 10.1093/eurjpc/zwab061.451.Peer-Reviewed Original ResearchCoronary inflammationRight coronaryFAI scoreCardiac mortalityPercentile curvesPrognostic valueCoronary artery disease indexHigh-risk plaque featuresCardiovascular prevention strategiesTraditional risk factorsCardiac computed tomographyBritish Heart FoundationFAI valuesMedian followInflammatory burdenCardiovascular riskAtherosclerotic changesCardiac deathAnterior descendingCircumflex arteryCoronary territoriesRisk stratificationPlaque featuresCoronary arteryMean age
2020
OP3 Improved cardiac risk stratification in individuals with high risk plaque features using the perivascular fat attenuation index on CCTA
Kotanidis C, Oikonomou E, Marwan M, Kluener L, Thomas K, Alashi A, Antonopoulos A, Shirodaria C, Neubauer S, Channon K, Achenbach S, Desai M, Antoniades C. OP3 Improved cardiac risk stratification in individuals with high risk plaque features using the perivascular fat attenuation index on CCTA. Heart 2020, 106: a1-a2. DOI: 10.1136/heartjnl-2020-bsci.3.Peer-Reviewed Original ResearchFat attenuation indexHigh-risk plaquesPerivascular fat attenuation indexAdjusted riskCardiac riskHRP featuresHigh-risk plaque featuresMajor adverse cardiac eventsProximal right coronary arteryAdditive predictive valueAdverse cardiac eventsLow-attenuation plaqueRight coronary arteryCardiac risk stratificationCox regression modelNapkin-ring signAdipose tissue compositionCoronary inflammationCardiac mortalityInflammatory burdenCardiac eventsSpotty calcificationRisk stratificationPlaque featuresCoronary artery
2019
Cardiac Computed Tomography
Oikonomou EK, West HW, Antoniades C. Cardiac Computed Tomography. Arteriosclerosis Thrombosis And Vascular Biology 2019, 39: 2207-2219. PMID: 31510795, DOI: 10.1161/atvbaha.119.312899.Peer-Reviewed Original ResearchConceptsCardiac computed tomographyComputed tomographyCoronary atherosclerosisCoronary plaque burdenAcute coronary syndromeCoronary artery diseaseFirst-line diagnostic testUnstable coronary plaquesMorphological plaque featuresCoronary syndromeInflammatory burdenArterial inflammationArtery diseaseCoronary lesionsPlaque burdenPlaque featuresPrognostic implicationsCoronary plaquesPerivascular fatHemodynamic significanceVulnerable plaquesDiagnostic testsMajor causeTomographyCurrent role