A novel arterial redox-specific machine learning-derived radiomic signature of perivascular adipose tissue predicts cardiac mortality from routine CCTA
Kotanidis C, Akawi N, Thomas S, Siddique M, Oikonomou E, Alashi A, Akoumianakis I, Antonopoulos A, Krasopoulos G, Sayeed R, Neubauer S, Channon K, Desai M, Antoniades C. A novel arterial redox-specific machine learning-derived radiomic signature of perivascular adipose tissue predicts cardiac mortality from routine CCTA. European Heart Journal 2020, 41: ehaa946.1372. DOI: 10.1093/ehjci/ehaa946.1372.Peer-Reviewed Original ResearchArterial oxidative stressMajor adverse cardiovascular eventsVascular redox stateInternal mammary arteryVascular oxidative stressCardiac riskArm 2Radiomics signatureOxidative stressArm 3Arm 1High-risk plaque featuresEpicardial adipose tissue volumeFat attenuation indexFuture cardiac riskRadiomic featuresAdverse cardiovascular eventsPerivascular adipose tissueCardiac risk predictionAdipose tissue volumeBritish Heart FoundationLucigenin-enhanced chemiluminescenceEx vivo quantificationLong-term riskAdipose tissue compositionPericoronary fat radiomic profile (FRP) predicts long-term cardiac risk in individuals with calcium score below 100 on coronary computed tomography angiography
Kotanidis C, Oikonomou E, Williams M, Thomas S, Thomas K, Lyasheva M, Antonopoulos A, Dweck M, Shirodaria C, Neubauer S, Channon K, Newby D, Antoniades C. Pericoronary fat radiomic profile (FRP) predicts long-term cardiac risk in individuals with calcium score below 100 on coronary computed tomography angiography. European Heart Journal 2020, 41: ehaa946.0181. DOI: 10.1093/ehjci/ehaa946.0181.Peer-Reviewed Original ResearchCoronary artery calciumCoronary artery diseaseHigh-risk plaquesAdipose tissue compositionArtery calciumCAC scoreCardiac riskTomography angiographyStudy populationLong-term cardiac riskMajor adverse cardiac eventsObstructive coronary artery diseaseSCOT-HEART trialAdverse cardiac eventsRisk of MACEAdverse clinical eventsTraditional risk factorsChronic vascular inflammationLow CAC scoresPericoronary adipose tissueCardiovascular risk assessmentLow-risk populationCox regression modelBritish Heart FoundationBiomedical Research CentreOP4 Perivascular fat attenuation index mapping around the right and left coronary artery independently predict cardiac mortality
Kotanidis C, Oikonomou E, Marwan M, Thomas K, Alashi A, Antonopoulos A, Shirodaria C, Neubauer S, Channon K, Achenbach S, Desai M, Antoniades C. OP4 Perivascular fat attenuation index mapping around the right and left coronary artery independently predict cardiac mortality. Heart 2020, 106: a2-a2. DOI: 10.1136/heartjnl-2020-bsci.4.Peer-Reviewed Original ResearchPerivascular fat attenuation indexFat attenuation indexCoronary arteryCoronary inflammationCardiac mortalityCardiac deathAnterior descending (LAD) coronary arteryEpicardial adipose tissue volumeFuture cardiac riskCox regression modelAdipose tissue volumeCross-sectional associationsAdipose tissue compositionMedian followProximal rightMultivariable adjustmentCardiac riskCoronary territoriesCoronary segmentsTomography angiographyIndependent associationHigh riskAverage ageArteryFuture incidenceOP3 Improved cardiac risk stratification in individuals with high risk plaque features using the perivascular fat attenuation index on CCTA
Kotanidis C, Oikonomou E, Marwan M, Kluener L, Thomas K, Alashi A, Antonopoulos A, Shirodaria C, Neubauer S, Channon K, Achenbach S, Desai M, Antoniades C. OP3 Improved cardiac risk stratification in individuals with high risk plaque features using the perivascular fat attenuation index on CCTA. Heart 2020, 106: a1-a2. DOI: 10.1136/heartjnl-2020-bsci.3.Peer-Reviewed Original ResearchFat attenuation indexHigh-risk plaquesPerivascular fat attenuation indexAdjusted riskCardiac riskHRP featuresHigh-risk plaque featuresMajor adverse cardiac eventsProximal right coronary arteryAdditive predictive valueAdverse cardiac eventsLow-attenuation plaqueRight coronary arteryCardiac risk stratificationCox regression modelNapkin-ring signAdipose tissue compositionCoronary inflammationCardiac mortalityInflammatory burdenCardiac eventsSpotty calcificationRisk stratificationPlaque featuresCoronary artery