Assessment of Prognostic Value of Left Ventricular Global Longitudinal Strain for Early Prediction of Chemotherapy-Induced Cardiotoxicity
Oikonomou EK, Kokkinidis DG, Kampaktsis PN, Amir EA, Marwick TH, Gupta D, Thavendiranathan P. Assessment of Prognostic Value of Left Ventricular Global Longitudinal Strain for Early Prediction of Chemotherapy-Induced Cardiotoxicity. JAMA Cardiology 2019, 4: 1007-1018. PMID: 31433450, PMCID: PMC6705141, DOI: 10.1001/jamacardio.2019.2952.Peer-Reviewed Original ResearchConceptsCancer therapy-related cardiac dysfunctionGlobal longitudinal strainLeft ventricular global longitudinal strainVentricular global longitudinal strainPrognostic valueCutoff valuePublication biasMeasurement of GLSNew-onset heart failure symptomsAbsolute global longitudinal strainWorse global longitudinal strainLarge prospective multicenter studyLeft ventricular ejection fractionDiscriminatory performanceLongitudinal strainChemotherapy-Induced CardiotoxicityGLS cutoff valueSubclinical ventricular dysfunctionHeart failure symptomsProspective multicenter studyVentricular ejection fractionCochrane Library databasesRisk of biasOptimal cutoff valueBetter prognostic performance