Alleles of Insm1 determine whether RIP1-Tag2 mice produce insulinomas or nonfunctioning pancreatic neuroendocrine tumors
Kobayashi S, Contractor T, Vosburgh E, Du YN, Tang LH, Clausen R, Harris CR. Alleles of Insm1 determine whether RIP1-Tag2 mice produce insulinomas or nonfunctioning pancreatic neuroendocrine tumors. Oncogenesis 2019, 8: 16. PMID: 30796198, PMCID: PMC6386750, DOI: 10.1038/s41389-019-0127-1.Peer-Reviewed Original ResearchPancreatic neuroendocrine tumorsNeuroendocrine tumorsRIP1-Tag2 transgenic miceBeta-cell transcription factorsRIP1-Tag2 miceC57BL/6 genetic backgroundCell linesExpression of Insm1Stem cell markersLiver metastasesNonfunctioning tumorsB6 miceLarge tumorsMetastatic tumorsSevere diseaseRT2 miceAnimal modelsInsulinomaTransgenic miceCell transcription factorsInsulin productionGenetic backgroundTumorsHuman insulinomasCell markers