2015
Estrogen in prefrontal cortex blocks stress-induced cognitive impairments in female rats
Yuen EY, Wei J, Yan Z. Estrogen in prefrontal cortex blocks stress-induced cognitive impairments in female rats. The Journal Of Steroid Biochemistry And Molecular Biology 2015, 160: 221-226. PMID: 26321384, PMCID: PMC4769981, DOI: 10.1016/j.jsbmb.2015.08.028.Peer-Reviewed Original ResearchConceptsPrefrontal cortexPFC of femalesStress-induced cognitive impairmentGlutamate receptor surface expressionSame stress paradigmCognitive behaviorMemory impairmentCognitive impairmentGlutamatergic deficitsStress paradigmFemale ratsLevels of aromataseContribution of estrogenNormal synaptic functionImpairmentReceptor surface expressionBiosynthesis of estrogensGlutamatergic transmissionPyramidal neuronsMale ratsEstrogen receptorCognitionHuman studiesProtective roleSynaptic function
2012
Parkin controls dopamine utilization in human midbrain dopaminergic neurons derived from induced pluripotent stem cells
Jiang H, Ren Y, Yuen E, Zhong P, Ghaedi M, Hu Z, Azabdaftari G, Nakaso K, Yan Z, Feng J. Parkin controls dopamine utilization in human midbrain dopaminergic neurons derived from induced pluripotent stem cells. Nature Communications 2012, 3: 668. PMID: 22314364, PMCID: PMC3498452, DOI: 10.1038/ncomms1669.Peer-Reviewed Original ResearchConceptsMidbrain DA neuronsDA neuronsParkinson's diseaseDopamine utilizationDopaminergic neuronsHuman midbrain dopaminergic neuronsSpontaneous DA releaseNigral DA neuronsNigral dopaminergic neuronsDisease-modifying therapiesMidbrain dopaminergic neuronsParkin knockout miceStem cellsPluripotent stem cellsPD patientsDA releaseDA neurotransmissionDA uptakeNormal subjectsKnockout miceParkin mutationsNovel targetNeuronsOxidative stressMonoamine oxidase