2011
Cellular Mechanisms for Dopamine D4 Receptor-induced Homeostatic Regulation of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors*
Yuen EY, Yan Z. Cellular Mechanisms for Dopamine D4 Receptor-induced Homeostatic Regulation of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors*. Journal Of Biological Chemistry 2011, 286: 24957-24965. PMID: 21622557, PMCID: PMC3137069, DOI: 10.1074/jbc.m111.221416.Peer-Reviewed Original ResearchConceptsGlutamatergic transmissionPFC neuronsPrefrontal cortexCalcium/calmodulin kinase II activityAMPAR responsesIsoxazolepropionic acid (AMPA) receptorsHomeostatic regulationCalmodulin kinase II activityAttention deficit hyperactivity disorderBi-directional regulationDopamine D4 receptorDeficit hyperactivity disorderAberrant dopaminePyramidal neuronsAMPA receptorsKinase II activitySynaptic currentsSynaptic targetingMental illnessAcid receptorsReceptor functionD4 receptorsCaMKII inhibitionActivity stateDistinct signaling mechanisms
2010
Delivery of GABAARs to Synapses Is Mediated by HAP1-KIF5 and Disrupted by Mutant Huntingtin
Twelvetrees A, Yuen E, Arancibia-Carcamo I, MacAskill A, Rostaing P, Lumb M, Humbert S, Triller A, Saudou F, Yan Z, Kittler J. Delivery of GABAARs to Synapses Is Mediated by HAP1-KIF5 and Disrupted by Mutant Huntingtin. Neuron 2010, 65: 53-65. PMID: 20152113, PMCID: PMC2841506, DOI: 10.1016/j.neuron.2009.12.007.Peer-Reviewed Original ResearchConceptsHuntingtin-associated protein 1Huntington's diseaseInhibitory postsynaptic currentsMutant huntingtinInhibitory synaptic currentsBrain excitabilityPostsynaptic currentsSynaptic inhibitionTherapeutic approachesSynaptic currentsDiseaseBrain information processingMolecular targetsSynapsesProtein 1Protein 5Protein huntingtinHuntingtinReceptorsPolyglutamine repeatsInhibitionGABAARsExcitability
2009
Acute stress enhances glutamatergic transmission in prefrontal cortex and facilitates working memory
Yuen EY, Liu W, Karatsoreos IN, Feng J, McEwen BS, Yan Z. Acute stress enhances glutamatergic transmission in prefrontal cortex and facilitates working memory. Proceedings Of The National Academy Of Sciences Of The United States Of America 2009, 106: 14075-14079. PMID: 19666502, PMCID: PMC2729022, DOI: 10.1073/pnas.0906791106.Peer-Reviewed Original ResearchConceptsAcute stressPrefrontal cortexGlucocorticoid receptorPotentiation of NMDARPFC pyramidal neuronsLong-term potentiationKey brain regionsCorticosteroid stress hormonesGR-dependent mechanismGlutamatergic transmissionPyramidal neuronsSynaptic transmissionBehavioral stressorsSynaptic currentsPFC neuronsBehavioral testsBrain regionsChronic stressAMPAR subunitsRecurrent excitationStress hormonesBeneficial effectsCellular mechanismsSurface expressionNMDAR
2005
Microtubule Regulation of N-Methyl-D-aspartate Receptor Channels in Neurons*
Yuen EY, Jiang Q, Feng J, Yan Z. Microtubule Regulation of N-Methyl-D-aspartate Receptor Channels in Neurons*. Journal Of Biological Chemistry 2005, 280: 29420-29427. PMID: 15975919, DOI: 10.1074/jbc.m504499200.Peer-Reviewed Original ResearchConceptsN-methyl-D-aspartate receptorsMicrotubule depolymerizerNMDAR currentsNMDA receptorsRole of microtubulesMicrotubule regulationActin cytoskeletonBrain-derived neurotrophic factorCellular knockdownNMDAR traffickingMicrotubule-depolymerizing agentCortical pyramidal neuronsN-methyl-D-aspartate receptor channelsDendritic transportHigh NMDA concentrationsMicrotubulesPyramidal neuronsNeurotrophic factorNMDAR functionNMDA concentrationSynaptic currentsNeuronal dendritesSynaptic plasticityMicrotubule stabilizerImmunocytochemical study