2011
Impaired α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) Receptor Trafficking and Function by Mutant Huntingtin*
Mandal M, Wei J, Zhong P, Cheng J, Duffney L, Liu W, Yuen E, Twelvetrees A, Li S, Li X, Kittler J, Yan Z. Impaired α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) Receptor Trafficking and Function by Mutant Huntingtin*. Journal Of Biological Chemistry 2011, 286: 33719-33728. PMID: 21832090, PMCID: PMC3190808, DOI: 10.1074/jbc.m111.236521.Peer-Reviewed Original ResearchConceptsMiniature excitatory postsynaptic currentsMouse modelMutant huntingtinAMPAR-mediated synaptic transmissionHuntington Disease PathophysiologyAMPAR-mediated miniature excitatory postsynaptic currentsExcitatory postsynaptic currentsTransgenic mouse modelHD mouse modelsIsoxazolepropionic acid receptor (AMPAR) traffickingReceptor traffickingAMPA receptor traffickingPolyQ-httGlutamatergic transmissionPostsynaptic currentsSynaptic excitationSynaptic transmissionAMPA receptorsWild-type huntingtinNeuronal culturesDisease pathophysiologySynaptic functionAMPAR traffickingΑ-aminoDiminished strength
2007
Serotonergic Regulation of NMDA Receptor Trafficking and Function in Prefrontal Cortex
Yuen E, Yan Z. Serotonergic Regulation of NMDA Receptor Trafficking and Function in Prefrontal Cortex. 2007, 91-101. DOI: 10.1007/978-0-387-72256-6_5.Peer-Reviewed Original ResearchPrefrontal cortexPFC neuronsBrain stem raphe nucleiPrimary neuronal populationsPyramidal projection neuronsNMDA receptor traffickingMultiple brain regionsProjection neuronsRaphe nucleusBasal gangliaBrain stemGABAergic interneuronsLimbic areasSerotonergic regulationWidespread projectionsNeuronal populationsFrontal lobeBehavioral testsBrain regionsDelayed-response taskCortexNeuronsMajor targetReceptor traffickingSerotonin