2010
Regulation of AMPA receptor channels and synaptic plasticity by cofilin phosphatase Slingshot in cortical neurons
Yuen EY, Liu W, Kafri T, Van Praag H, Yan Z. Regulation of AMPA receptor channels and synaptic plasticity by cofilin phosphatase Slingshot in cortical neurons. The Journal Of Physiology 2010, 588: 2361-2371. PMID: 20442266, PMCID: PMC2915513, DOI: 10.1113/jphysiol.2009.186353.Peer-Reviewed Original ResearchMeSH KeywordsActinsAnimalsCells, CulturedCerebral CortexCofilin 1ElectrophysiologyExcitatory Postsynaptic PotentialsImmunohistochemistryLentivirusMicrofilament ProteinsNeuronal PlasticityNeuronsPhosphoric Monoester HydrolasesRatsReceptors, AMPARNA, Small InterferingRNA, ViralSynapsesSynaptic TransmissionConceptsExcitatory postsynaptic currentsCortical neuronsSynaptic transmissionSynaptic plasticityReceptor-mediated excitatory postsynaptic currentsAMPA receptor-mediated excitatory postsynaptic currentsPhosphatase SlingshotActin dynamicsAMPA receptor channelsFunction-blocking antibodiesSmall RNA interferenceAMPAR EPSCsMajor actin depolymerizing factorPostsynaptic currentsCofilin phosphatase SlingshotGluR-1Synaptic functionActin depolymerizing factorSpine morphologyAMPAR traffickingReceptor channelsActin cytoskeletonRNA interferenceNeuronsCofilin activation
2005
Microtubule Regulation of N-Methyl-D-aspartate Receptor Channels in Neurons*
Yuen EY, Jiang Q, Feng J, Yan Z. Microtubule Regulation of N-Methyl-D-aspartate Receptor Channels in Neurons*. Journal Of Biological Chemistry 2005, 280: 29420-29427. PMID: 15975919, DOI: 10.1074/jbc.m504499200.Peer-Reviewed Original ResearchConceptsN-methyl-D-aspartate receptorsMicrotubule depolymerizerNMDAR currentsNMDA receptorsRole of microtubulesMicrotubule regulationActin cytoskeletonBrain-derived neurotrophic factorCellular knockdownNMDAR traffickingMicrotubule-depolymerizing agentCortical pyramidal neuronsN-methyl-D-aspartate receptor channelsDendritic transportHigh NMDA concentrationsMicrotubulesPyramidal neuronsNeurotrophic factorNMDAR functionNMDA concentrationSynaptic currentsNeuronal dendritesSynaptic plasticityMicrotubule stabilizerImmunocytochemical study